DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and slc22a2

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_998315.1	Gene:	slc22a2 / 406424	ZFINID:	ZDB-GENE-040426-2167	Length:	562	Species:	Danio rerio

Alignment Length:	558	Identity:	196/558 - (35%)
Similarity:	280/558 - (50%)	Gaps:	66/558 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRC------------------ 49
            ::|.:...|.|||.|..|:...||.|||.:|..:..||....|:..|
Zfish     4 FEEILEEAGTFGRSQIRIFCTFCLVSIPFSFVYVGIVFQGFTPEHWCRDPGVSEIRERCGWSLQD 68

  Fly    50 ----ALPFENGSSYDLPTHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSS-NETK-------TC 102
                .:|..||||        ..||   .:|..:|||:....|:...|... |:::       :|
Zfish    69 ARRATVPLINGSS--------GASY---SQCGRFDVDWNATGLSCENPDGDFNQSQLSVMPMMSC 122

  Fly   103 -SSYVYDRSKYL--NSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGR-KPILFA 163
             ..:.||   |:  .|.|||::||||..:......:...:|.|:|||..|.|:||||| |..|..
Zfish   123 VDGWEYD---YVGRQSFVTEFDLVCGDAWYVDMFQATLSIGFLVGSIAIGYLADKYGRMKSFLMT 184

  Fly   164 SLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSV 228
            :..|.|. |:|...:|.|.:....|.:.|....|.::|.||:..|:||.|.|...|:...:|||:
Zfish   185 NFFIGVT-GILVATSPNYISLLVFRALFGFGVKGGWMVGYVLITELVGVDHRRTVGVTYQLFFSM 248

  Fly   229 GFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKV 293
            |.:|..:.|||:.:|||||:..|:|.:.|:.|||.||||.||||.:                ||:
Zfish   249 GILLLPLLAYFITNWRWLQVVFTVPYICFLTYYWFIPESPRWLLTQ----------------NKI 297

  Fly   294 EISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVY 358
            ..:.|....:..|...:..|..:.|:|..:|.|...|..|||....||..|.::..:|..::.||
Zfish   298 AEAVEITKSIAKENRKTLSKKIETLKDDNIDSGSTASFMDLFKTAKLRTYTFILSFNWFTSAVVY 362

  Fly   359 YGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQR 423
            .||......|||||.::|:|||.||:||...:|||:.|.|||.......::||.:.|.|..||..
Zfish   363 QGLIMRLGILGGNVYVDFLISGIVELPAAFLILLTIERIGRRLPFATANIVAGAACLITAFIPDS 427

  Fly   424 MHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIW 487
            |..|..|.|.:|:|.||.::..|...:.|.:|||:||:.:...|.:..:.|::||||.: ||.||
Zfish   428 MFWLKSAVACVGRLGITMAFEMVVFVNTELYPTVIRNLGVSVCSTLCDVGGIVAPFLLYRLAVIW 492

  Fly   488 KPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGE 525
            ..|||:|.|:|..|||.|.||||||...|:.|||.|.|
Zfish   493 LELPLIIFGALAFVAGGLVLLLPETKGVPLPETIDDIE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	190/543 (35%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	138/377 (37%)
slc22a2	NP_998315.1	2A0119	12..525	CDD:273328	190/543 (35%)
slc22a2	NP_998315.1	MFS	146..515	CDD:119392	143/385 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588702
Domainoid	1	1.000	280	1.000	Domainoid score	I1640
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850