DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	536	Identity:	182/536 - (33%)
Similarity:	289/536 - (53%)	Gaps:	33/536 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFE-NGSSY----DLP 62
            ||:....||.:|.:|..::..:.::.:|..|..|..||:...|...|.:|.: |.||.    .:|
Zfish     4 YDDITSFLGTWGPFQLTVFLALAISILPNGFVGLYIVFVGDTPAHECLIPEQINISSVWRDAAIP 68

  Fly    63 THLWNLSYPENERCSYYDVD---------YTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNSAV 117
            |.:.: ...:...||.|.:|         ||.   |..:..|..||:.| ..:.|.:..|.::.|
Zfish    69 TQMQD-GVLKRSSCSRYRLDTLRQLSMLNYTP---NVEVNLSQIETEPCVDGWSYSQEFYQSTIV 129

  Fly   118 TEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYF 182
            |||:|||.|::....:.|::..|||:|:.:.||:||:|||:|:||..:.:|.:..::...:|.:.
Zfish   130 TEWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSPSWE 194

  Fly   183 TYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLTAVFAYFVHDWRWL 246
            .::.....||.:....::||||:..|::.|..| |:..:.|.|...:|.|...:.|||:..||||
Zfish   195 VFSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGSGIGQMFFPLAAYFIRSWRWL 259

  Fly   247 QIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSE 311
            .:...|.||::...:|.||||.||||.:||...|.|.:::||..|:|     ...|::......|
Zfish   260 VLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRV-----TAPEVIFSSSEIE 319

  Fly   312 EKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNF 376
            |.||::::..        |:.|:....|.....|:..|.|:|.:..||.|..||:||.||..|||
Zfish   320 EAAKKRIQKH--------SILDILSNCNAVSTILICSLLWMVITMSYYALILNTTNLHGNPYLNF 376

  Fly   377 VISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITA 441
            .:|..||:||||...|.|....||......|::.|..:....:||..:..|..|..|||||.:||
Zfish   377 FLSAVVEVPAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEMLGKLCVTA 441

  Fly   442 SYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLS 506
            ::..||..::|.|||||||:|:|:.||.|||..:::||:.:|...::.:|.::.|.|.|.:|::|
Zfish   442 AFCVVYAVTSELFPTVVRNMAMGSCSMTARIGSIISPFIIYLGNYYRYIPYIVIGGLALFSGVMS 506

  Fly   507 LLLPETHNKPMLETIA 522
            |||||:..|.:.||||
Zfish   507 LLLPESKGKVLPETIA 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	175/524 (33%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	130/376 (35%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	175/524 (33%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	134/378 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588461
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870