DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and slc22a7b.1

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_021322800.1	Gene:	slc22a7b.1 / 393320	ZFINID:	ZDB-GENE-040426-1311	Length:	560	Species:	Danio rerio

Alignment Length:	570	Identity:	176/570 - (30%)
Similarity:	279/570 - (48%)	Gaps:	47/570 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:|..:.....|||||..:..|:.:..|.:..|.|...|:.|.|...|.:     ||.| ...|
Zfish    11 MKFDNILDETDGFGRYQIALVMLLFIPRITIPCHFLLNNFIAAIPSHHCDI-----SSLD-ADGL 69

  Fly    66 WNL--------SYPENE-----RCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAV 117
            .||        |.|..|     .|..:.....:..:|.|...:....:..:.:.:|.|.::::..
Zfish    70 GNLTQKERLIVSVPAQEDGTPASCHMFAHPQFQLLINSSSSSALPVVECQNGWHFDNSTFISTLA 134

  Fly   118 TEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYF 182
            |:::|||.:..:|..|.::|.:||:.|::.||.|.|||||:.:|..|.|..::|.|.:..:..|.
Zfish   135 TQFDLVCDKRGLAKASATIFFVGVMCGAVFFGVLCDKYGRRSMLLVSYVFSIVFSVTSAFSSSYI 199

  Fly   183 TYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQ 247
            .:...|.:.|...:|:..::.|:::|.|....|.:.|:|..|.:|:|.||.|.||:.|.|||.|.
Zfish   200 MFAAFRFLTGLALTGISNISVVLSIEWVDTKHRTFMGLFGSMSWSIGNMLLAGFAFMVTDWRLLI 264

  Fly   248 IALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNK-----VEISDEALSELLDEG 307
            :.:|.|..:....:|.||:|||||:..|:.:.|...:.|.|.||:     ..:..|.||.::...
Zfish   265 VIVTAPLFLATATWWWIPDSARWLIANGKTETAYKYLHKCATFNQRLDFTSRVKPETLSTVVTVD 329

  Fly   308 ENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNV 372
            .                .|...:..||...|.||:.||...:.|...:..|||:|.|.:..|.:.
Zfish   330 H----------------RGHSYTYLDLVKTPQLRKLTLFTGIVWYGVASTYYGISLNITGFGLDP 378

  Fly   373 LLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKL 437
            .|...|..|:|:||.|.:..:||:.|||:...|.||:.|..:|..:|.|....|.....|:|||.
Zfish   379 YLTHFIYAAIEVPAKILVYFSLNKVGRRNTQTGTLVLTGFCILINIITPTEYWTFRTVIAVLGKG 443

  Fly   438 AITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVA 502
            ...||:.||.:::.|.:|||:|...||..:.:||:...::|.:..|..|||.||.:|..|:.:..
Zfish   444 LSEASFTTVILYTTELYPTVMRQNGLGFTNFMARMGASISPLIMLLEDIWKLLPEVIFCSMAIFC 508

  Fly   503 GLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLK 552
            |:::||||||:|..:.||:.|.|...||   .||..|..:    .|.|||
Zfish   509 GIIALLLPETNNASLPETVEDIEDMRKK---PVYFTTADQ----SAMPLK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	161/526 (31%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	122/380 (32%)
slc22a7b.1	XP_021322800.1	Sugar_tr	22..526	CDD:331684	161/525 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.980