Protein Alignment Orct2 and SLC22A25

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_016873173.1
• Gene: SLC22A25 / 387601
• HGNCID: 32935
• Length: 577
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 154/600 - (25%)
• Similarity: 265/600 - (44%)
• Gaps: 98/600 - (16%)

  Fly     1 MGYDEAIIHLGDFGRYQKI-IYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH 64
            |.:.:.:..:|..||:|.: :.|||....|  .:|:               ...||.:::.|...
Human     1 MAFQDLLDQVGGLGRFQILQMVFLIMFNVI--VYHQ---------------TQLENFAAFILDHR 48

  Fly    65 LW-----NLSYPENE----------RCSY-YDVDYTEE-------------YLNGSIPRSSN-ET 99
            .|     |.:.|:|:          |.|. :|.:...|             :|||:.|.:|. :|
Human    49 CWVHILDNDTIPDNDPGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDT 113

  Fly   100 KTC-SSYVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDK--------- 154
            :.| ..:|||:|.:.::.||:|:|||....:.:.:..|||.|:::|..::|.|||:
Human   114 EPCVDGWVYDQSSFPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHV 178

  Fly   155 ---------------------YGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGV 198
                                 :|||.:|..|.:...:.|..|..||....|...|.:.||.|..:
Human   179 STDCDEGLEVPIAIHQHHVFWFGRKFVLRWSYLQLAIVGTCAAFAPTILVYCSLRFLAGAATFSI 243

  Fly   199 FLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWI 263
            .:...::.:|.:.......|....:...|:|.:.....|:.:.|...||:.::.|..:|..:...
Human   244 IVNTVLLIVEWITHQFCAMALTLTLCAASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLFSRW 308

  Fly   264 IPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALS-ELLDEGENSEEKAKQKLEDQELDEGP 327
            :.||||||::..:.:..:..::|||..|.::.:::.|: |:|......|.:|.||..
Human   309 LAESARWLIINNKPEEGLKELRKAAHRNGMKNAEDILTMEVLKSTMKQELEAAQKKH-------- 365

  Fly   328 PPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLL 392
              |:.:|...||:.::...:......::..::||:.:..:||.||.|...:.|||.:.|......
Human   366 --SLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPW 428

  Fly   393 TLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLG----KLAITASYGTVYIFSAEQ 453
            .||...||......:.:....|||.:.:||.|.||.|..|.||    .|.||.|...    ..|.
Human   429 ALNHMSRRLSQMLLMFLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQ----ENEL 489

  Fly   454 FPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPML 518
            .|:::|..|.|.....|.|.|.:|..:..|:...:|||.:|.|...:::||:.||||||.|:|:|
Human   490 IPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETRNQPLL 554

  Fly   519 ETIADGERFGKKTKA 533
            ::|.|.|..|..:.|
Human   555 DSIQDVENEGVNSLA 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	148/575 (26%)
		MFS	127..503	CDD:119392	100/410 (24%)
SLC22A25	XP_016873173.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940