DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and CG10486

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	161/557 - (28%)
Similarity:	274/557 - (49%)	Gaps:	55/557 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQ-KIIYFLICLTSIPVAFHKLAGVFL-LAKPDFRCALPFENGSSYDLPTHL 65
            :|:.:..:|.|||:| ::..|:|....| .||..|..:|: |..|.:.|.:|    .....|..|
  Fly    96 FDDLLPMIGQFGRFQIRLFLFMIPFCFI-TAFVYLGQIFMCLTPPKYYCYVP----ELLHTPVEL 155

  Fly    66 -WNLSYPENE-----RCSYYDVDYTE--------EYLNGSIPRSSNETKTC-SSYVYDR-SKYLN 114
             ..||.|:.:     ||..|:.:||:        .|:|.|:|     |..| ..||::: .:...
  Fly   156 RKELSIPKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLP-----TIPCKKGYVFEQEGRAFE 215

  Fly   115 SAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAP 179
            ||..|:..:|..|..|..:..:|.||.:||.:.:|..:|..||...|.:|..:.::..:...::.
  Fly   216 SATMEFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMST 280

  Fly   180 EYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLTAVFAYFVHDW 243
            ::||:..:|.:|||:....|.:.|::.:|.|||..| |.|.:.:.:|:|...|:....|....:|
  Fly   281 DFFTFAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNW 345

  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGE 308
            |......:||.::.||.:.::|||||||:..|..|.|:..::.....||.::|    .|:||..|
  Fly   346 RRFSSFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVS----KEILDLFE 406

  Fly   309 NS-EEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGG-N 371
            .| .:..|::|:.::.      :|..:|....:.|..:|:.|.|:..|.||.|.....|.|.. |
  Fly   407 ASCTQFYKEELDGRDF------TVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSEN 465

  Fly   372 VLLNFVISGAVEIPAYIFLLLTLNRWGRR------SILCGCLVMAGLSLLATVIIPQRMHTLIVA 430
            :.|.|.|:.|.|:|..|.::|||:|.|||      :.|.|...:.|.|.       |....:.::
  Fly   466 IFLFFTIACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFSLLGASF-------QNRANMRMS 523

  Fly   431 CAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLIC 495
             |:.|:......|.....::||..|||||...:.....:..::.:|:|.:.:|:.......|::.
  Fly   524 -ALAGRFFSNICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVL 587

  Fly   496 GSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTK 532
            |:|.:..|||:|.||||.|..:.||::||.:|||..:
  Fly   588 GALGIFGGLLALFLPETLNHELPETLSDGAQFGKNQR 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	153/535 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	106/384 (28%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	153/535 (29%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	109/388 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458400
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.890