DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and CG4630

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001260948.1	Gene:	CG4630 / 36458	FlyBaseID:	FBgn0033809	Length:	582	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	191/587 - (32%)
Similarity:	317/587 - (54%)	Gaps:	75/587 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-------FENGSS 58
            :.:|:.::.:|:|||:|:..|.||||..:..|.:.|:.||....|.:||.:|       .|.|::
  Fly    13 LDFDDILVEIGEFGRFQRRNYLLICLPVLFAAANSLSYVFTAGSPTYRCYVPECDKLVDAEYGAN 77

  Fly    59 YDLPTHLW-NLSYPEN-ERCSYYDVDYTEEYL-NGSIPRSSN------------------ETKTC 102
                   | :::.|.: .:..::.....|.:: ||....||:                  ||:.|
  Fly    78 -------WVSIAVPGSWSKRGHFTPSTCERFVANGDHLESSSDPWSAWPLDQCFAENFTTETERC 135

  Fly   103 SSYVYDRSKYLNSAVTEWNLVCGRD-FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLV 166
            :.:||..|:  .:.|.:|.|.|..: :..|...::...|:::|:.:.|.|:|:||||.|....:|
  Fly   136 NQFVYGSSE--RTIVQQWGLQCPENLWKLAFVGTIHFAGLVVGTALSGYLADRYGRKHIFLFCIV 198

  Fly   167 IQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFM 231
            ...|.||...::.:|.::.|..|:....||||:.:|:::.:|||||.||..:.|.:..|::||..
  Fly   199 FMALTGVAQALSWDYISFLFFALLNAVGTSGVYPLAFIIGVEMVGPRKREMSSIVLNYFYAVGEA 263

  Fly   232 LTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEIS 296
            |..: :.|:.|||.||:||::|.||.:.|:|::|||.||||.:.|::.|...:::||:.|:.:||
  Fly   264 LLGL-SVFLPDWRQLQLALSVPPLICVAYFWLVPESVRWLLARNRREQAGVIIRRAAKVNRRDIS 327

  Fly   297 DEALSEL----LDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLL------IFLDW 351
            .|.::..    ||.....|:..:..|..::.|:     :|  .....:.|..:|      :.|.|
  Fly   328 VELMASFKQQELDAETGQEDDVEGGLHVKKDDK-----IW--LAVKEVARSHILMGRYAILLLIW 385

  Fly   352 LVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLA 416
            .|.:.||||||.|.::|.||..|||.:...||||.|....|.|.|:|||..|.|.|::..::.:|
  Fly   386 AVNAIVYYGLSLNATSLSGNKYLNFALVCLVEIPGYSLAWLFLRRFGRRVALSGSLLLCSITCVA 450

  Fly   417 TVIIP-------------QRMHT------LIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVA 462
            :..:.             :..|:      |:|...::|||.||:|:..:|.|:||..|||:|:..
  Fly   451 SGFVTLAQGDWIPCQTGVESRHSWSCANWLVVTLFLVGKLGITSSFAVIYTFTAEMMPTVIRSGG 515

  Fly   463 LGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERF 527
            :|..|..||...|:|||:..||:.:.|||||:.|:|:|||||||||||||.|:.:.:|:.:....
  Fly   516 VGVMSTFARFGAMLAPFVPLLASYYDPLPLLLFGTLSLVAGLLSLLLPETFNRKLPDTVEEAIAL 580

  Fly   528 GK 529
            ||
  Fly   581 GK 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	187/566 (33%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	138/405 (34%)
CG4630	NP_001260948.1	2A0119	23..573	CDD:273328	187/566 (33%)
CG4630	NP_001260948.1	MFS	158..533	CDD:119392	126/382 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458338
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	9	8.900