DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Balat

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_610823.1	Gene:	Balat / 36417	FlyBaseID:	FBgn0033778	Length:	604	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	181/554 - (32%)
Similarity:	305/554 - (55%)	Gaps:	44/554 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICL-TSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH 64
            |.:||.:..:|.||.|||:|...:.| .::|.|||..:.:|:.|.|...|.:|.....:.|....
  Fly     1 MDFDEVLREVGSFGLYQKVIICSVLLPAALPCAFHAYSQLFIAATPQHFCRVPELEPWTQDYVQL 65

  Fly    65 LWNLSYPENE-----RCSYYDVDYTE--EYLNGSIP---------------RSSNETKTCS-SYV 106
            :.|||.|.|.     .||.|..:||:  .||....|               ..:.:...|. .:.
  Fly    66 VKNLSIPRNRNGAYAECSMYSRNYTDIVRYLEYRPPPDLLRQQAEDLLKLQPDTTQVVPCQHGWH 130

  Fly   107 YDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLF 171
            ||:|.|.::.|.||||||.|.|:...:..:|.:|.|||:.|||.|.|.:||:|..:|.|:::::.
  Fly   131 YDKSIYSSTVVQEWNLVCDRSFLVTLALVVFGVGGLLGNYVFGYLVDLWGRRPSFYAYLLLEIIA 195

  Fly   172 GVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVF 236
            ...:..|..|:|:...|.:||.|...:....||:|:|:|||::|::..|...:.:|:|.::.|..
  Fly   196 CAASAFAWNYYTWLGLRFVVGLTVPAILASPYVLAIELVGPERRVFCTIVSNIAYSLGLVVLAGV 260

  Fly   237 AYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALS 301
            .|.|.|||.|.:|:::|.|:....::::|||.|||:..|:...||..::..||.|.|.::.:.:
  Fly   261 IYIVRDWRELSLAVSMPLLMLFSCFFVLPESPRWLMAVGKTRRAIKILKVMARVNGVRVNRDFV- 324

  Fly   302 ELLDEGENSEEKAKQKLEDQELDEGPPP-----SVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGL 361
                      |:.::||......|....     .:.|||..||:|||||:|.|.|...:.||.||
  Fly   325 ----------ERLQRKLVITRAAETKSSMTTHYGILDLFRGPNMRRKTLIITLIWFANTSVYVGL 379

  Fly   362 SWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHT 426
            |:....|||:.:.||.::||||:|.|:.|...|:.:|||.||...:::.|::.:||.:.|.  .|
  Fly   380 SYYAPALGGDEIWNFFLAGAVELPTYLLLWPGLSYFGRRWILFISMLVGGVACVATFLYPD--IT 442

  Fly   427 LIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLP 491
            |::.|  :||:.|::|:..:.:.::|.:|||||.:.:..:|:::.:..::.|.:|.:......||
  Fly   443 LLLYC--VGKMGISSSFVVLPLMASELYPTVVRGLGMSFSSVISMVGPIVIPMINHMGQQMLVLP 505

  Fly   492 LLICGSLTLVAGLLSLLLPETHNKPMLETIADGE 525
            |::.|:|.::.|..|||||||.|:.:.:|:.:||
  Fly   506 LIVMGALLILGGFASLLLPETRNRNLPQTLEEGE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	175/537 (33%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	122/380 (32%)
Balat	NP_610823.1	MFS_SLC22	128..524	CDD:340875	138/410 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458418
Domainoid	1	1.000	225	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E33208_3B9N9
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I1021
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm8406
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
	10	9.920