DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	569	Identity:	153/569 - (26%)
Similarity:	258/569 - (45%)	Gaps:	76/569 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGDFGRYQKIIYFLICLTSIP---VAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLSYP 71
            :|:||.:|   :.|:.||.||   ..|..|:..|||.     ...|:.|.|        |.|...
  Rat    58 IGEFGTFQ---WRLVALTFIPSILSTFFLLSHHFLLT-----AQRPYCNTS--------WILQVG 106

  Fly    72 ENERCSYYDVDYTE-EYLNGSIPRSS-------------------------NETKTCS-SYVYDR 109
            .|         .|| |.||.::||:.                         |.|:||. .::|..
  Rat   107 PN---------LTEDEQLNLTVPRAPNGSFLTCLMYIPVPWDLDSIVHFGLNYTETCKHGWIYPF 162

  Fly   110 SKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVL 174
            : :..|...|::||||.:.......::|:.|:|.||::||.||||.||.||:..||:..::||..
  Rat   163 A-HTRSLTNEFDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFG 226

  Fly   175 AGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYF 239
            ......::.|.|.|..|...:.|..:.:..:.||.:..:.|..|.|....||::|.:|...|||.
  Rat   227 TAFVNSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAIILQHCFFTIGVILLTGFAYK 291

  Fly   240 VHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELL 304
            ::.||.|.:...:|....:...|::.||.|||::||:.:.|...:..||..||..|....|:||.
  Rat   292 INHWRLLFLLGGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNKKTIPLNLLNELQ 356

  Fly   305 DEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLG 369
            ..|    :|||             .|:.|.:...:|.:..|.:...|...|.|...||....:.|
  Rat   357 LPG----KKAK-------------ASILDFYTNQHLFKVVLAMGCVWFTVSYVSLTLSLKMKDFG 404

  Fly   370 GNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAML 434
            .::....|:.....:||.:..:|.|..:||:..|...|.:...:.|:.:.:|:.:.:..:...:|
  Rat   405 LDIYFIQVVPCITAVPARLCCILLLEYFGRKWSLNLTLSLVTFTCLSLLFVPEELKSTTILMLVL 469

  Fly   435 GKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLT 499
            |:.::..:....:|::||..||::|:..||..| :|..:|.::....|..|..: ||:..|....
  Rat   470 GEFSMAGTVSIFFIYTAELLPTILRSTGLGMVS-IAWTAGAISSLAIFKQTKTQ-LPIFFCCLCC 532

  Fly   500 LVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEA 548
            ::|...|.|:|||.|:|:.::|....|...:.| |...::.:.|.|.|:
  Rat   533 ILALCFSSLVPETGNQPLRDSIEYCSRDSLEHK-DKSKDSSKVLMAEES 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	146/538 (27%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	100/375 (27%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	110/399 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020