DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	183/580 - (31%)
Similarity:	282/580 - (48%)	Gaps:	72/580 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLIC-LTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTH 64
            |..:||...:|:.|.||..:.||:. |..:.||...:....:.|.|.:.          :|:...
  Rat     1 MEVEEAFQAVGEMGLYQMYLCFLLAVLLQLYVATEAILIALIGATPAYH----------WDMAEL 55

  Fly    65 LWNLSYPENERCSYYDVDYTEEYL--NGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRD 127
            |.|.|:  :.:.|.....:.:..|  |||         ....:|:..:.: .|..:||.|:..|.
  Rat    56 LPNQSH--SNQSSGKGQAFGDWLLTANGS---------EIHKHVHFSNSF-TSIASEWFLIANRS 108

  Fly   128 FMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVG 192
            :..:.:.|.|..||.:|.|.||||||::|||.:......:.:||.:..|.:|.|..:...|.:||
  Rat   109 YKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVG 173

  Fly   193 ATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIF 257
            ....|:.|||:|:..|.||......||....:||:||....|:..||:..||.|.|.:.|.|.:.
  Rat   174 MMNGGMSLVAFVLLNECVGAAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVV 238

  Fly   258 MFYYWIIPESARWLLLKGRKDCAIANMQKAARFNK-----VEISDEALSELLDEGENSEEKAKQK 317
            ......||||.|||..:||...|...:...|:.|:     ..::..|.....:.|
  Rat   239 FLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRKLKCTFSLTHPANRSYRETG---------- 293

  Fly   318 LEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAV 382
                        |..|||.|..|...||::...|.|.|.|||||:.:..:|||::..|..:||.:
  Rat   294 ------------SFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLI 346

  Fly   383 EIPAYIFLLLTLN-RW-GRRSILCGCLVMAGLSLLATVIIPQRMHTLIVA------CAMLGKLAI 439
            |||:|...:..:| || ||:..|...|.:.||:.|..:.:|::..|.:.|      .::||||.|
  Rat   347 EIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTI 411

  Fly   440 TASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGL 504
            :|::..|||:::|.:|||:|||.||..||.:|:.|::|||:..|..:...||.::.|:..|.:||
  Rat   412 SAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPSLKDVQWSLPFIVFGATGLTSGL 476

  Fly   505 LSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEA----QPLKGSGETNGS 560
            ||||||||.|.|:|||.:|.:.:.       |...|:|..:.:.    ||| |...:.||
  Rat   477 LSLLLPETLNSPLLETFSDLQMYS-------YRRLGEEALSLQTLDPPQPL-GKASSLGS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	168/524 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	129/388 (33%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	127/379 (34%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	121/360 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347056
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.850