DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	567	Identity:	192/567 - (33%)
Similarity:	309/567 - (54%)	Gaps:	64/567 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWN 67
            |||.|..||::|.:|::|:||:..:.||..|:.::.|||...|:.||.:|    .:.:|.:...|
Mouse     4 YDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVP----DTVNLSSSWRN 64

  Fly    68 LSYPEN--------ERCSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .|.|..        :.|..|                 |||.  |.|         |.::| ..:.
Mouse    65 HSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDL--EQL---------EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLF 171
            ||:..:|::.||||||||..|:....:.|||.:|||.||.|.|||||::|||.:|||::.:|..|
Mouse   119 YDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGF 183

  Fly   172 GVLAGVAP--EYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLT 233
            ..:...:.  |.||..||  :||......::||:::..|::....| :::.:.|..||::|:|:.
Mouse   184 SFVQIFSTNWEMFTVLFA--IVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVL 246

  Fly   234 AVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDE 298
            .:||||:.|||.|.:|||||||..:..:|.||||.|||:.:.|...|...:||||:.|.: ::..
Mouse   247 PLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSI-VAPA 310

  Fly   299 ALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSW 363
            .:.:.|:..|.:..|.::.:            :.|||...|:...|::..:.|::||..|:.||.
Mouse   311 GIFDPLELQELNSLKQQKVI------------ILDLFRTRNIATITVMAVMLWMLTSVGYFALSL 363

  Fly   364 NTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI 428
            |..||.|:|.||..:||.:|:|||....|.|....||.|:.|.|...|..||...::|:..:.:.
Mouse   364 NVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVS 428

  Fly   429 VACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLL 493
            :...||||..||:::..:|:|:||.:||:|||:|:|..||.:|:..::||:..:|....:.||.:
Mouse   429 IGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYI 493

  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETIAD-----GERFGKKTKADV 535
            :.||||::.|:::|..||:....:.|.:..     |.|.|||:...|
Mouse   494 LMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSV 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	180/537 (34%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	136/378 (36%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	180/536 (34%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	147/401 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843604
Domainoid	1	1.000	282	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820