DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and Slc22a17

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_803156.2	Gene:	Slc22a17 / 305886	RGDID:	631405	Length:	520	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	137/527 - (25%)
Similarity:	224/527 - (42%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VFLLAKPDFRC---ALPFENGSSYDLPTHLWNLSYPENERCSYYD-----------VDYTEEYLN 89
            :|.|| |...|   ||| .|.|.::.|        |.:...|...           |..|:...:
  Rat     6 IFTLA-PPLHCHYGALP-PNASGWEQP--------PNSSGVSVAGAALAASAASRVVTSTDPSCS 60

  Fly    90 GSIPRSSNETKTC-SSYVYDRSKYL-NSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLS 152
            |..|...|.   | ..:.|:....| .:|:.:|:|||...:.......||:||...|.:..|..:
  Rat    61 GFAPPDFNH---CLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPA 122

  Fly   153 DKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLY 217
            |::||:.|:..:|.:....||....|.........|.::|...:||.|..|::.:|:..|.:||.
  Rat   123 DRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMTLRFLLGFLLAGVDLGVYLMRLELCDPTQRLR 187

  Fly   218 AGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYW--IIPESARWLLLKGRKDCA 280
            ..:...:....|..|....|....|||:||..:|.|.::|:||.|  :..||||||::|.:.:.|
  Rat   188 VALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEA 252

  Fly   281 IANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRR--- 342
            .:.::..|..|:            ..|:...|:|::.|  |||:...|......|.:.:|..
  Rat   253 QSVLRILAERNR------------PHGQMLGEEAQEAL--QELENTCPLPTTSTFSFASLLNYRN 303

  Fly   343 --KTLLIFLDWLVTSGVYYGLSWNTSNLGGN------VLLNFVISGAVEIPAYIFLLLTLNRWGR 399
              |.|||.   ..|:.:.:.:......:||.      .|.:.:.||...: |.:||.:|::|:||
  Rat   304 IWKNLLIL---GFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAAL-ACVFLGVTVDRFGR 364

  Fly   400 RSILCGCLVMAGLSLLATVIIPQRMH-TLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVAL 463
            |.||...:.:.|::.|..:.:...:: ..|...::||..:..||.....:.:||..||.||...|
  Rat   365 RGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLAAEVIPTTVRGRGL 429

  Fly   464 GAASMVARISGMMAP----------FLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPML 518
            |....:..:.|:..|          ||..:.       |..|..|.:   |..:|||||..|.:.
  Rat   430 GLIMALGALGGLSCPAQRLHMGHGAFLQHVV-------LAACALLCI---LSIMLLPETKRKLLP 484

  Fly   519 ETIADGE 525
            |.:.|||
  Rat   485 EVLRDGE 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	133/520 (26%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	100/399 (25%)
Slc22a17	NP_803156.2	MFS	106..476	CDD:119392	102/397 (26%)
Slc22a17	NP_803156.2	2A0114	111..475	CDD:273326	97/391 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940