Protein Alignment Orct2 and Slc22a22

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001013969.1
• Gene: Slc22a22 / 299944
• RGDID: 1304605
• Length: 555
• Species: Rattus norvegicus
• Alignment Length: 574
• Identity: 150/574 - (26%)
• Similarity: 268/574 - (46%)
• Gaps: 58/574 - (10%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPF------ENGSSY 59
            |.:||.:.|:||.||:|..:..::.:.|:..:.|.:...|..|.|...|::..      |...:.
  Rat     1 MAFDEILHHVGDRGRFQIWMIVVLNILSMVSSLHDVIENFTAAIPAHHCSVNLLDTSRSEISMAM 65

  Fly    60 DLPTH-LWNLSYP-----ENERCSYYDVDYTEEYLNGSIPRSSN---ETKTC-SSYVYDRSKYLN 114
            :|.|. :..:|.|     :.|:|..:..... ::::.:|..|::   ||:.| ..:.||.|.:.:
  Rat    66 NLTTEAMMKVSIPMGPNQKPEQCRRFRHPQW-QFIDSNISTSNSTELETEPCLDGWTYDHSVFTS 129

  Fly   115 SAVTEWNLVCGRDFMA------ATSDSLFMLGVLLGSIVFGQLSDKYGRKPIL-FASLVIQVLFG 172
            :.||||:|||  ||.:      |||    :.|..:.:...|.:||::||||:| :.||...:| |
  Rat   130 TIVTEWDLVC--DFQSFKYYAQATS----LAGHFVAAPFCGIISDRFGRKPLLMYCSLAYGIL-G 187

  Fly   173 VLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVM--MFFSVGFMLTAV 235
            ......|.:..|...|.:..|:.|.|.:...::.:|..  ..:.:|.:.|:  :|.|.|......
  Rat   188 TCCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEET--SVQWHATVIVLSGLFSSTGLAGLGG 250

  Fly   236 FAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-KVEISDEA 299
            .||.:.||..:|:...||..||...:..:|||||||::.|:.|.|:..:|:.|..| |.:|:...
  Rat   251 LAYVLSDWHLIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQRIASINGKKDIAQNL 315

  Fly   300 LSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTL----LIFLDWLVTSGVYYG 360
            .:|.|          :.|:::.........|:.|:...|.:|:..|    ::|.:..    ..:|
  Rat   316 TTEDL----------RSKVKEDVCSTVKHFSIKDIIINPMIRKIVLCYSSVLFAELF----SIFG 366

  Fly   361 LSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMH 425
            |..:...||.|:.:..::.|.::||:.......|....||.::...|...|..:..|:.:.:.|:
  Rat   367 LLLDVHMLGKNIFVTQILLGVIDIPSKSLTYFILRNVRRRPLIAFLLFATGGCITITMFLSEDMY 431

  Fly   426 TLIVACAMLGK--LAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWK 488
            .|.:|..:|||  .|...|..|.|  ..|..|..:|:...|....|||::.:::.........:.
  Rat   432 VLRLAIFILGKGCFAAFISINTAY--CNELSPVPLRSTLNGIYISVARLASVLSALTLVTRKYFV 494

  Fly   489 PLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQE 542
            .||::.||.|.:||.:....||||.|.|:.:||.|.|:..:....::..:.||:
  Rat   495 LLPMIFCGVLPIVATINIYFLPETFNHPITDTIKDMEKRNRLMSKNISEKEGQD 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	140/540 (26%)
Slc22a22	NP_001013969.1	MFS_OAT	109..516	CDD:340932	114/431 (26%)