DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	175/577 - (30%)
Similarity:	280/577 - (48%)	Gaps:	45/577 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:::.:..:|..||:|.|...::....:.:|.|.....|..|.|...|..|.....|.|.....
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    66 W----NLSYPENERC-SYYDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSKYLNSAVTEWNLVC 124
            |    ....||:  | .:....:...:.||:....:..|:.| ..:|||.|.:.::.||||||||
  Rat    66 WLPLDKQGQPES--CLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVC 128

  Fly   125 GRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARL 189
            ........:.||:|:|||||::|||.|:|:.||:.:|..:.:...:.|..|..||.|..|...||
  Rat   129 SHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRL 193

  Fly   190 MVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPG 254
            :.|.:.:.:.:....:.:|.:....|.|.|..:...:|:|..|.|..||.|..||.||:.:::|.
  Rat   194 LSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPF 258

  Fly   255 LIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLE 319
            .|...|.|...|||||....||.|..:..:|:.||.|                ...||.||..:|
  Rat   259 FIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARIN----------------GKQEEGAKLSIE 307

  Fly   320 --------DQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNF 376
                    :..|.:| ..|..:|...|.||...|.:.:.|..||..||||..:....|.::.|..
  Rat   308 VLRTSLQKELTLSKG-QASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQ 371

  Fly   377 VISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI-VACAMLGKLAIT 440
            ||.|||::||.....|.:|..|||......|::||:.:|...||| :.||:| .:.|:|||..:.
  Rat   372 VIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIP-KSHTIIRTSLAVLGKGCLA 435

  Fly   441 ASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLL 505
            :|:..:::::.|.:|||:|...||..|.:||:..:::|.::..|..:..:||.|.|::.:||..:
  Rat   436 SSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAV 500

  Fly   506 SLLLPETHNKPMLETIAD--GERFGKKTKADVYLETGQELRAPEAQPLKGS-GETNG 559
            :.|||||..:|:.:|:.|  ....||:.:.       |:.:..:..||:.| .|.||
  Rat   501 TALLPETLGQPLPDTVQDLKSRSRGKQNQQ-------QQEQQKQMMPLQASTQEKNG 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	163/523 (31%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	122/384 (32%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	163/523 (31%)
		MFS	135..505	CDD:119392	124/387 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		11/44 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347126
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950