DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_062103.1	Gene:	Slc22a3 / 29504	RGDID:	3701	Length:	551	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	184/573 - (32%)
Similarity:	293/573 - (51%)	Gaps:	74/573 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDF-------------RCALPFE 54
            :|:|:...|:|||:|:.::.|:|||.:..||..:..|||.::||:             |||..
  Rat     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWS-- 66

  Fly    55 NGSSYDLPTHLWNLSYPE----NER-----CSYY---DVDYTEEYLN----GSIPRSSNETKTCS 103
                   |...|||:.||    .||     |..|   |.:.:.| |:    .:.|..|.....||
  Rat    67 -------PEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSE-LSCDPLAAFPNRSAPLVPCS 123

  Fly   104 S---YVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASL 165
            .   ||...|    :.|::::||||..:|...:.::..||.|.|:...|..:|:|||..:...|.
  Rat   124 GDWRYVETHS----TIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISC 184

  Fly   166 VIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGF 230
            ....:.||:...||.:..:...|.:.|....|.::..:|:..|:||..:|...||.:.|||::|.
  Rat   185 FGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGI 249

  Fly   231 MLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEI 295
            ::....|||...|:.:|:|::||..:|:.|||::|||.|||:.:.:.:.|:..:::.|:.|...:
  Rat   250 IILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHL 314

  Fly   296 SDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYG 360
            |.. .||:             .:.|:|:..   ||..||...|.:|:.||::...|..::.||.|
  Rat   315 SSN-YSEI-------------TVTDEEVSN---PSCLDLVRTPQMRKCTLILMFAWFTSAVVYQG 362

  Fly   361 LSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMH 425
            |......:|||:.::|.|||.||:|..:.:|||:.|.|||.......::||:|.|.|..:|:.:.
  Rat   363 LVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIP 427

  Fly   426 TLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKP 489
            .|....|.||:|.||.::..||:.::|.:||.:||..:...|.:....|::||||.| ||.||..
  Rat   428 WLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLE 492

  Fly   490 LPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFG----------KKTK 532
            |||:|.|.|..|.|.|.:|||||....:.||:.|.|:.|          |||:
  Rat   493 LPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	174/541 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	123/376 (33%)
Slc22a3	NP_062103.1	2A0119	12..523	CDD:273328	174/541 (32%)
Slc22a3	NP_062103.1	MFS	145..513	CDD:119392	126/384 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347134
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900