DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a20

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001381833.1	Gene:	Slc22a20 / 293686	RGDID:	1311460	Length:	556	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	181/570 - (31%)
Similarity:	291/570 - (51%)	Gaps:	35/570 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL 65
            |.:.:.:..||..||:|.:...|:.|....:|.|.....|..|.|...|..|.....:....:..
  Rat     1 MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAAPPHHCQHPANYTEATTNDSGA 65

  Fly    66 W-NLSYPEN-----ERCSYYDVDYTEEYLNGSIPRSSNE---TKTC-SSYVYDRSKYLNSAVTEW 120
            | ..:.|.|     |.|.    .|||.......|.:|:.   |:.| ..:|||||.:.::.|.||
  Rat    66 WLRATIPLNQHGVPEPCQ----RYTEPQWALLEPNTSSHGVATEGCKDGWVYDRSIFPSTIVMEW 126

  Fly   121 NLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRK-PILFASLVIQVLFGVLAGVAPEYFTY 184
            :|||....:...:.|::|.|||:|:.:||.|:|:.||| |::::.|.:.|...|.|.|. .:..|
  Rat   127 DLVCEARTLRDLAQSIYMSGVLVGAALFGSLADRLGRKAPLVWSYLQLAVSGAVTAYVG-SFSAY 190

  Fly   185 TFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIA 249
            ...|.::|.|.||:.|.:..:.:|.:....|..|||.:...|::|.::.|..||.:..|||||.|
  Rat   191 CIFRFLMGMTFSGIILNSLSLVVEWMPTRGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQFA 255

  Fly   250 LTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKA 314
            ::.|.|:|..|.|.:|||:|||||.|:...|:.|::|.|..|..:...|.|         :.|..
  Rat   256 VSAPFLVFFLYSWWLPESSRWLLLHGKAQQAVQNLRKVAMMNGRKAEGERL---------TIEVV 311

  Fly   315 KQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVIS 379
            ...::::........|:.|||..|.:|:.|..:.:.|...|..||||:.:....|.::.|...:.
  Rat   312 SSYIQNEFASVRTSNSILDLFRTPGIRKVTCCLMMVWFSNSVAYYGLAMDLQKFGLSIYLVQALF 376

  Fly   380 GAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYG 444
            |.::|||.:....|:...|||:.:...||:|||.::|.:.:|:.:.||....|.|||..:.:|:.
  Rat   377 GIIDIPAMLVATTTMIYVGRRATVSSFLVLAGLMVIANMFVPEDLQTLRTVQAALGKGCLASSFI 441

  Fly   445 TVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSL-L 508
            .||:|:.|.:||.:|.:.:|.||:.||:.|:.||.:..|..|...||.:..|:.:::||:..: .
  Rat   442 CVYLFTGELYPTEIRQMGMGFASVNARLGGLAAPLITTLGEISPVLPPVSFGATSVLAGMAVICF 506

  Fly   509 LPETHNKPMLETIADGERFGKK--TKADVYLETG----QELRAPEAQPLK 552
            |.||.|.|::||||..|...|:  :|.|...:..    |:|.||   |||
  Rat   507 LTETRNVPLVETIAAMESRVKEGHSKRDTEQKNEEISLQQLGAP---PLK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	164/520 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	121/376 (32%)
Slc22a20	NP_001381833.1	MFS_SLC22A6_OAT1_like	103..508	CDD:341004	136/414 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850