DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and SLC22A24

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001129978.2	Gene:	SLC22A24 / 283238	HGNCID:	28542	Length:	552	Species:	Homo sapiens

Alignment Length:	549	Identity:	162/549 - (29%)
Similarity:	268/549 - (48%)	Gaps:	28/549 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-FENGSSYDLPT- 63
            ||:|..:..:|..||:|..:....|:|:|.:..:.:...|....|..||.:| .:|.:..|..|
Human     1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTG 65

  Fly    64 -----HLWNLSYP-----ENERCS-YYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRSKYLNS 115
                 .|..:|.|     ..::|. :....:...:|||:.|.::. :|:.| ..:|||||.:|::
Human    66 TLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSSFLST 130

  Fly   116 AVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPE 180
            .||||:|||....:.:...||||.|.|||.:::|.|||:.|||.|.....:...:....|..||.
Human   131 IVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPT 195

  Fly   181 YFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRW 245
            :..|...|.:.|.:|..:....:::::|...|..|....:.::..:|||.||....|:.:.||..
Human   196 FLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHI 260

  Fly   246 LQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEAL-SELLDEGEN 309
            ||:.::.|.::.....|.:.||||||::..:.|..:..:::.|..|..:.::|.| :||:
Human   261 LQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELV----- 320

  Fly   310 SEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTL-LIFLDWLVTSGVYYGLSWNTSNLGGNVL 373
             ....|::|:...:    ..|::.||..|.||.:.. |.|:.:.:|. .:|||..|..:||.||.
Human   321 -RSTMKKELDAVRI----KTSIFSLFRAPKLRMRVFGLCFVRFAITV-PFYGLILNLQHLGSNVS 379

  Fly   374 LNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLA 438
            |..::.|||...|....|||||..|||..........||.:|....:||.|..|.|..|.||..:
Human   380 LFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGS 444

  Fly   439 ITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAG 503
            ::|:..:..:...|..||::|:...|..::..|....:||.|..|......||.:..|...::|.
Human   445 VSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAV 509

  Fly   504 LLSLLLPETHNKPMLETIADGERFGKKTK 532
            .:.||||||.:.|:..||.|.|...|.::
Human   510 PVILLLPETRDLPLPNTIQDVENDRKDSR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	154/525 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	108/377 (29%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	126/417 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153523
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940