Protein Alignment Orct2 and SLC22A24

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001129978.2
• Gene: SLC22A24 / 283238
• HGNCID: 28542
• Length: 552
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 162/549 - (29%)
• Similarity: 268/549 - (48%)
• Gaps: 28/549 - (5%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-FENGSSYDLPT- 63
            ||:|..:..:|..||:|..:....|:|:|.:..:.:...|....|..||.:| .:|.:..|..|
Human     1 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVSDNDTG 65

  Fly    64 -----HLWNLSYP-----ENERCS-YYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRSKYLNS 115
                 .|..:|.|     ..::|. :....:...:|||:.|.::. :|:.| ..:|||||.:|::
Human    66 TLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGWVYDRSSFLST 130

  Fly   116 AVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPE 180
            .||||:|||....:.:...||||.|.|||.:::|.|||:.|||.|.....:...:....|..||.
Human   131 IVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCFLQLAISNTCAAFAPT 195

  Fly   181 YFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRW 245
            :..|...|.:.|.:|..:....:::::|...|..|....:.::..:|||.||....|:.:.||..
Human   196 FLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCSYSVGQMLLGGLAFAIQDWHI 260

  Fly   246 LQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEAL-SELLDEGEN 309
            ||:.::.|.::.....|.:.||||||::..:.|..:..:::.|..|..:.::|.| :||:
Human   261 LQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELRRVAHINGKKNTEETLTTELV----- 320

  Fly   310 SEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTL-LIFLDWLVTSGVYYGLSWNTSNLGGNVL 373
             ....|::|:...:    ..|::.||..|.||.:.. |.|:.:.:|. .:|||..|..:||.||.
Human   321 -RSTMKKELDAVRI----KTSIFSLFRAPKLRMRVFGLCFVRFAITV-PFYGLILNLQHLGSNVS 379

  Fly   374 LNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLA 438
            |..::.|||...|....|||||..|||..........||.:|....:||.|..|.|..|.||..:
Human   380 LFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGLFILVNTFLPQEMQILRVVLATLGIGS 444

  Fly   439 ITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAG 503
            ::|:..:..:...|..||::|:...|..::..|....:||.|..|......||.:..|...::|.
Human   445 VSAASNSASVHHNELVPTILRSTVAGINAVSGRTGAALAPLLMTLMAYSPHLPWISYGVFPILAV 509

  Fly   504 LLSLLLPETHNKPMLETIADGERFGKKTK 532
            .:.||||||.:.|:..||.|.|...|.::
Human   510 PVILLLPETRDLPLPNTIQDVENDRKDSR 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	154/525 (29%)
SLC22A24	NP_001129978.2	MFS_OAT	109..516	CDD:340932	126/417 (30%)