DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	194/570 - (34%)
Similarity:	298/570 - (52%)	Gaps:	54/570 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHL-WN 67
            |:.:..:|:||.:||..:.|:||.|..:|...:..|||...|...|    :|....:|.... |:
  Rat     5 DDVLEQVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPGHYC----QNPGVAELSQRCGWS 65

  Fly    68 ----LSY------PENE-----RCSYYDVDYTEEYLNGSIPRSS---NETK----TCS-SYVYDR 109
                |:|      |.:|     :|..|:||:.:..|:...|.||   |.::    .|. .:|||.
  Rat    66 QAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGPCEHGWVYDT 130

  Fly   110 SKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVL 174
            ..  :|.|||:|||||..:......|...||..|||:|.|.::|::|||..|..:.::..:.|||
  Rat   131 PG--SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSVSGVL 193

  Fly   175 AGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYF 239
            ..|||:|.:....||:.|..:.|.::..|.:..|.||...|....|...|.|:||.:..|..||.
  Rat   194 TAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAGVAYA 258

  Fly   240 VHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-KVEISDEALSEL 303
            :.||||||:|::||..:|:.|||.:|||.||||.:.|...|:..|::.|:.| ||..:|  |..|
  Rat   259 IPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPAD--LKML 321

  Fly   304 LDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNL 368
            ..|.:.||:::              ||..|||..||||:.|:::...|...:.:|.||..:....
  Rat   322 CLEEDASEKRS--------------PSFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHVGAT 372

  Fly   369 GGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAM 433
            |.|:.|:|..|..||.||...:|:|::|.||...:....::.|.:.|..:.||..:|.|.|..|.
  Rat   373 GANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIPHELHWLNVTLAC 437

  Fly   434 LGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICGS 497
            ||::..|.....|.:.:||.:||.:||:.:...|.:..:.|:..||:.| |..:|:.|||::.|.
  Rat   438 LGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGV 502

  Fly   498 LTLVAGLLSLLLPETHNKPMLETIADGERFG-KKTKA---DVYL--ETGQ 541
            |.|.||.::||||||....:.|||.:.|..| :|:||   .:||  :||:
  Rat   503 LGLTAGAMTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	181/534 (34%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	129/377 (34%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	181/534 (34%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	145/407 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347086
Domainoid	1	1.000	272	1.000	Domainoid score	I1731
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900