DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and SV2C

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_055794.3	Gene:	SV2C / 22987	HGNCID:	30670	Length:	727	Species:	Homo sapiens

Alignment Length:	685	Identity:	122/685 - (17%)
Similarity:	217/685 - (31%)	Gaps:	267/685 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLS 69
            |.||.....||:|..::|::             |:.|:|
Human   139 ELIIQECGHGRFQWALFFVL-------------GMALMA-------------------------- 164

  Fly    70 YPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSD 134
                        |..|.::.|.:..|: ||..|          :.::.:.|            ..
Human   165 ------------DGVEVFVVGFVLPSA-ETDLC----------IPNSGSGW------------LG 194

  Fly   135 SLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVF 199
            |:..||:::|:..:|.|:||.|||..|...:.:...|..|:.....|..:.|.||:.|....|..
Human   195 SIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLFCRLLSGFGIGGAI 259

  Fly   200 LVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVF----------------AYFVHDWRWLQI 248
            ...:....|::..:||.....::.||:.:|.:..:..                ||..|.||...|
Human   260 PTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVI 324

  Fly   249 ALTLPGLIFMFYYWIIPESARWLLLKGRKDCA--------IANM------QKAARFNKVEISDEA 299
            ...||.:..:.....:|||.|:||..|:.|.|        ..||      :|....||::...:
Human   325 VCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQ- 388

  Fly   300 LSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRK-------------------TL 345
                :||           |.:.|.|.|    .|...|:..:|.:                   |:
Human   389 ----IDE-----------LIEIESDTG----TWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTI 434

  Fly   346 LIFLDWLVTSGVYYGLS-W---------------NTSNLGGNVLLNFVISGAVE----------- 383
            .:.:.|...|..||||| |               .|.|:..:...||.|:..:|
Human   435 KLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDN 499

  Fly   384 ----------------------------------------------------------------- 383

Human   500 GRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFH 564

  Fly   384 -----------------------------IPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVI 419
                                         :|..|...|.::|.||.::|.|.:|::|:|......
Human   565 NKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWF 629

  Fly   420 IPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFL-NFL 483
            .......:.:.|...| |.|:| :.::.:.:.|.:||..|....|..:.:.:.:.::...: ..|
Human   630 GTSESMMIGMLCLYNG-LTISA-WNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSL 692

  Fly   484 ATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPML 518
            .:|.|.:|:|:..::.:..||:.|.||:|..:.::
Human   693 VSITKSIPILLASTVLVCGGLVGLCLPDTRTQVLM 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	119/679 (18%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	98/546 (18%)
SV2C	NP_055794.3	synapt_SV2	1..727	CDD:130366	122/683 (18%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..84
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128
		MFS	155..719	CDD:119392	113/659 (17%)
		Pentapeptide_3	507..561	CDD:290309	0/53 (0%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:27294781	519..563		0/43 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940