DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_036015188.1	Gene:	Slc22a22 / 210463	MGIID:	2446114	Length:	587	Species:	Mus musculus

Alignment Length:	605	Identity:	155/605 - (25%)
Similarity:	270/605 - (44%)	Gaps:	88/605 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSS-----YD 60
            |.:||.:.|:||.||:|..:..|:.:.|:.::.|.:...|..|.|...|::..:|..|     .:
Mouse     1 MDFDEILHHVGDSGRFQICMIILLNILSLVLSPHDVLENFTAAIPAHHCSINLDNSRSEVSTDMN 65

  Fly    61 LPTH-LWNLSYP-----ENERCSYYDVDYTE-EYLNGSIPRSSN---ETKTC-SSYVYDRSKYLN 114
            |.|. |..:|.|     :.|:|..:  .||: ::|:.:|...::   ||:.| ..:.||.|.:.:
Mouse    66 LTTEDLMKVSIPMGPNQKPEQCRRF--RYTQWQFLDSNISTFNSTELETEPCLDGWTYDHSVFTS 128

  Fly   115 SAVTE---------------------------------WNLVCGRDFMA------ATSDSLFMLG 140
            :.|||                                 |:|||  ||.:      |||    :.|
Mouse   129 TIVTEGLSPPQPWDSDQYYHTKHEISPCEEGLKSSVKVWDLVC--DFQSFKYYAQATS----LAG 187

  Fly   141 VLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVV 205
            .|:...:.|.:||::||||:|....:.....|.....||.:..|...|.::.|..|.:.:.:.::
Mouse   188 HLVSCPLSGIISDRFGRKPLLMYCSLAYGAVGTYCAFAPNFSVYCVLRFLLSAFQSTILINSLIL 252

  Fly   206 AMEMVGPDKRLYAGIFVM--MFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESA 268
            .:|..  ..:.:..|.|:  :|.|:|..:....||.:.||..||:|..||..||...:..:|||.
Mouse   253 VLEEA--SVQWHPTIIVLSGLFNSIGQGVLGGLAYVISDWHLLQLAYALPFFIFFVLFCWVPESV 315

  Fly   269 RWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWD 333
            |||::.|:.|.|...:|:.|..|    ..:.:::.|     :.|..:.||:......|....:.|
Mouse   316 RWLIITGKTDQAWKELQRIASIN----GKKGIAQNL-----TTEDLRSKLKKDVNSTGKLFRIKD 371

  Fly   334 LFCYPNLRRKTL----LIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTL 394
            :|..|.:|:..|    |:|.:..    .:.||..:...||.|:.|..:..||:::|:......|:
Mouse   372 IFINPLIRKIVLSNSSLLFAELF----SFVGLLLDVQLLGKNMFLTQIFLGAIDVPSKSLTYFTI 432

  Fly   395 NRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGK--LAITASYGTVYIFSAEQFPTV 457
            ....||.::...|:..|..:..|:.|.:.|:.|.....:|||  .|......|.||  .|..|..
Mouse   433 RNVSRRPLIAFLLLTTGSCITITIFISEEMYVLRTIIFILGKGCFAAFTCISTTYI--NELSPVE 495

  Fly   458 VRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIA 522
            :|:...|....|.|::|:::.........:..||:::.|.|.:||.:..|.||||.|.|..:.|.
Mouse   496 LRSTLNGVFLAVVRLAGVLSALTLATRKYFVYLPMILYGVLPIVATISILFLPETFNLPHTDIIK 560

  Fly   523 DGERFGKKTKADVYLETGQE 542
            |.|:..:....::..:.||:
Mouse   561 DMEKRKRLMSKNISKKEGQD 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	146/571 (26%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	100/389 (26%)
Slc22a22	XP_036015188.1	MFS_OAT	108..548	CDD:340932	115/462 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5838
OMA	1	1.010	-	-		QHG48025
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.910