Protein Alignment Orct2 and Slc22a12

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_033229.3
• Gene: Slc22a12 / 20521
• MGIID: 1195269
• Length: 553
• Species: Mus musculus
• Alignment Length: 540
• Identity: 161/540 - (29%)
• Similarity: 262/540 - (48%)
• Gaps: 28/540 - (5%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-FENGSSY----- 59
            |.:.|.:..:|..||:|......:....:.|....:...|..|.|..||.:| .:|.:|.
Mouse     1 MAFPELLDRVGGLGRFQLFQTVALVTPILWVTTQNMLENFSAAVPHHRCWVPLLDNSTSQASIPG 65

  Fly    60 DL-PTHLWNLSYP-----ENERCSYY---DVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKYL 113
            || |..|..:|.|     :..:|..:   ....||.  |.:... |...|:.| ..:|||.|.:.
Mouse    66 DLGPDVLLAVSIPPGPDQQPHQCLRFRQPQWQLTES--NATATNWSDAATEPCEDGWVYDHSTFR 128

  Fly   114 NSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVA 178
            ::.||.|:|||....:...:.|:|:.|:|:|:.|.|..||::||:.:|..|.::..:.|..|...
Mouse   129 STIVTTWDLVCNSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTAAAFM 193

  Fly   179 PEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDW 243
            |.:..|...|.::.:..:||.:....:.||...............:.||.|.:||...||.|..|
Mouse   194 PTFPLYCLFRFLLASAVAGVMMNTASLLMEWTSAQGSPLVMTLNALGFSFGQVLTGSVAYGVRSW 258

  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGE 308
            |.||:|::.|..:|..|.|.:|||||||:..|:.|..:..:|:.|..|:.:...:.|
Mouse   259 RMLQLAVSAPFFLFFVYSWWLPESARWLITVGKLDQGLQELQRVAAVNRRKAEGDTL-------- 315

  Fly   309 NSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVL 373
             :.|..:..:|::...:....|:..|...|.||.:|::..|.|......:|||:.:...||.|:.
Mouse   316 -TMEVLRSAMEEEPSRDKAGASLGTLLHTPGLRHRTIISMLCWFAFGFTFYGLALDLQALGSNIF 379

  Fly   374 LNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLA 438
            |...:.|.|:.|.....||.::|.|||......||:.||.:|:.:::|..|..|..|.|:||...
Mouse   380 LLQALIGIVDFPVKTGSLLLISRLGRRLCQVSFLVLPGLCILSNILVPHGMGVLRSALAVLGLGC 444

  Fly   439 ITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAG 503
            :..::..:.|||:|.||||:|..|:|...:.||...|:.|.:..|......:|||:.|.:.:::|
Mouse   445 LGGAFTCITIFSSELFPTVIRMTAVGLCQVAARGGAMLGPLVRLLGVYGSWMPLLVYGVVPVLSG 509

  Fly   504 LLSLLLPETHNKPMLETIAD 523
            |.:||||||.|.|:.:||.|
Mouse   510 LAALLLPETKNLPLPDTIQD 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	156/525 (30%)
Slc22a12	NP_033229.3	MFS_OAT	109..516	CDD:340932	127/415 (31%)