DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	548	Identity:	182/548 - (33%)
Similarity:	299/548 - (54%)	Gaps:	59/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWN 67
            |||....||::|.:|::|:||:..:.||..|:.::.|||...|:.||.:|    .:.:|.:...|
Mouse     4 YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVP----HTVNLSSAWRN 64

  Fly    68 LSYPEN--------ERCSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .|.|..        ::|..|                 |||.  |.|         |.::| ..:.
Mouse    65 HSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDL--EQL---------EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLF 171
            ||:..:|::.||||:|||..|:.|..:.|||.:|||:||.:.|||||::|||.:||.::.:|..|
Mouse   119 YDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGF 183

  Fly   172 GVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLTAV 235
            ..|...:..:..:|...::||......::.|:|:..|::....| ::|.:.|.:|::.|||:..:
Mouse   184 SFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPL 248

  Fly   236 FAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEAL 300
            ||||:.|||.|.:|||:||::....:|.||||.|||:.:||...|...::|||:.|.:    .|.
Mouse   249 FAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGI----VAP 309

  Fly   301 SELLDEGENSEEKAKQKLEDQELDEGPPP--SVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSW 363
            |.:.|..|.           |:|:...|.  .::||....|:|..|::..:.||..|..|:|||.
Mouse   310 STIFDPSEL-----------QDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSL 363

  Fly   364 NTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI 428
            :|.||.|::.:|..:..|||:|||:...|.|....||..:...|.:.|..||...::|..:..|.
Mouse   364 DTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLS 428

  Fly   429 VACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLL 493
            .|..|:||..||::|..||:::||.:||||||:.:|.:|..:|:..:::|:..:|....:.||.:
Mouse   429 TALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYI 493

  Fly   494 ICGSLTLVAGLLSLLLPETHNKPMLETI 521
            :.||||::..:|:|..||:...|:.:||
Mouse   494 LMGSLTILTAILTLFFPESFGVPLPDTI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	176/537 (33%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	132/378 (35%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	176/537 (33%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	142/401 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843605
Domainoid	1	1.000	282	1.000	Domainoid score	I1643
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2273
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm11112
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.820