Protein Alignment Orct2 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_035525.1
• Gene: Slc22a3 / 20519
• MGIID: 1333817
• Length: 551
• Species: Mus musculus
• Alignment Length: 572
• Identity: 183/572 - (31%)
• Similarity: 290/572 - (50%)
• Gaps: 72/572 - (12%)

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDF-------------RCALPFE 54
            :|:|:...|:|||:|:.::.|:|||.:..||..:..|||.::||:             |||..
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWS-- 66

  Fly    55 NGSSYDLPTHLWNLSYPE----NER-----CSYYDVDYTEEYLNGS------IPRSSNETKTCSS 104
                   |...|||:.||    .||     |..|.::.|......|      .|..|....:||.
Mouse    67 -------PEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCSG 124

  Fly   105 ---YVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLV 166
               ||...|    :.|::::|||...:|...:.::..||.|.|:...|..:|:|||..|...|..
Mouse   125 DWRYVETHS----TIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIIYLISCF 185

  Fly   167 IQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFM 231
            ...:.||:...||.:..:...|.:.|....|.::..:|:..|:||..:|...||.:.|||::|.:
Mouse   186 GVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGII 250

  Fly   232 LTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEIS 296
            :....|||...|:.:|:|::||..:|:.|||::|||.|||:.:.:.:.|:..:::.|:.|...:|
Mouse   251 ILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLS 315

  Fly   297 DEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGL 361
            .. .||:             .:.|:|:..   ||..||...|.:|:.||::...|..::.||.||
Mouse   316 SN-YSEI-------------TVTDEEVSN---PSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGL 363

  Fly   362 SWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHT 426
            ......:|||:.::|.|||.||:|..:.:|||:.|.|||.......::||:|.|.|..:|:.:..
Mouse   364 VMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPW 428

  Fly   427 LIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPL 490
            |....|.||:|.||.::..||:.::|.:||.:||..:...|.:....|::||||.| ||.||..|
Mouse   429 LRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLEL 493

  Fly   491 PLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFG----------KKTK 532
            ||:|.|.|..|.|.|.:|||||....:.||:.|.|:.|          |||:
Mouse   494 PLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQ 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	173/540 (32%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	173/540 (32%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		3/3 (100%)