Protein Alignment Orct2 and Slc22a2

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_038695.1
• Gene: Slc22a2 / 20518
• MGIID: 1335072
• Length: 553
• Species: Mus musculus
• Alignment Length: 561
• Identity: 185/561 - (32%)
• Similarity: 287/561 - (51%)
• Gaps: 45/561 - (8%)

  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDL---PTHL 65
            |:.:.|:|:|..:||..:||:.|.|.......:..|||...|:..|..|.....|...   |...
Mouse     5 DDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPNHHCRSPGVAELSQRCGWSPAEE 69

  Fly    66 WNLSYPE---------NERCSYYDVDYTEEYLNGSIPRSS---NET----KTCS-SYVYDRSKYL 113
            .|.:.|.         ..:|..|:||:.:..|:...|.||   |.:    ..|. .:|||...
Mouse    70 LNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPG-- 132

  Fly   114 NSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVA 178
            :|.|||:||||...:|.....||..:|..:|::..|.|:|::|||..|..:::|..:.|||..::
Mouse   133 SSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAISGVLMAIS 197

  Fly   179 PEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDW 243
            |.|......|.:.|..:...:|:.|::..|.||...|...||...:.|:||.::.|..||.:.:|
Mouse   198 PNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFTVGLLILAGVAYALPNW 262

  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN--KVEISDEALSELLDE 306
            ||||.|:|||...|:.|:|.||||.|||:.:.:...|:..::..|:.|  .|.:|.::|:
Mouse   263 RWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSLQSLT----- 322

  Fly   307 GENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGN 371
               ::|....||.         ||..||...|.:|:.||::..:|..:|.:|.||..:....|.|
Mouse   323 ---ADEDTGMKLN---------PSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDN 375

  Fly   372 VLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGK 436
            :.|:|..|..||.||...::||::|.|||.......::||.:.||:|.||..:..|.:..|.||:
Mouse   376 IYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITVACLGR 440

  Fly   437 LAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICGSLTL 500
            :.||.:|..|.:.:||.:||.:||:|:...|.:..|.|::.|||.: |..||...||::...:.|
Mouse   441 MGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGL 505

  Fly   501 VAGLLSLLLPETHNKPMLETIADGERF---GKKTKADVYLE 538
            |||.|.||||||..|.:.|||.|.|:.   .||.:..:||:
Mouse   506 VAGGLVLLLPETKGKALPETIEDAEKMQRPRKKKEKRIYLQ 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	174/531 (33%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	174/531 (33%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		3/3 (100%)