Protein Alignment Orct2 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 566
• Identity: 194/566 - (34%)
• Similarity: 293/566 - (51%)
• Gaps: 46/566 - (8%)

  Fly     4 DEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDL---PTHL 65
            |:.:.|:|:||.:||..:.|:||.|..:|...:..|||...||..|..|.....|...   |...
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHCRSPGVAELSQRCGWSPAEE 69

  Fly    66 WNLSYPE---------NERCSYYDVDYTEEYLNGSIPRSS---NET----KTCS-SYVYDRSKYL 113
            .|.:.|.         ..:|..|:||:.:..|:...|.||   |.:    ..|. .:|||...
Mouse    70 LNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSPCEHGWVYDTPG-- 132

  Fly   114 NSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVA 178
            :|.|||:|||||..:......|...||..|||:|.|.::|::|||..|..:.::..|.|||..||
Mouse   133 SSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLSGVLTAVA 197

  Fly   179 PEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDW 243
            |:|.:....||:.|..:.|.::..|.:..|.||...|....|...:.|:||.:..|..||.:.||
Mouse   198 PDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAGVAYAIPDW 262

  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFN-KVEISDEALSELLDEG 307
            ||||:|::||..:|:.|||.:|||.||||.:.|...|:..|::.|:.| ||..:|  |..:..|.
Mouse   263 RWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRKVPPAD--LKMMCLEE 325

  Fly   308 ENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNV 372
            :.||.::              ||..|||..|:||:.||::...|...:.:|.||..:....|.|:
Mouse   326 DASERRS--------------PSFADLFRTPSLRKHTLILMYLWFSCAVLYQGLIMHVGATGANL 376

  Fly   373 LLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKL 437
            .|:|..|..||.||...:|:|::|.||...:....::||.:.|..:.||..:|.|.|..|.||::
Mouse   377 YLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIPHELHWLNVTLACLGRM 441

  Fly   438 AITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF-LATIWKPLPLLICGSLTLV 501
            ..|.....|.:.:||.:||.:||:.:...|.:..:.|:..||:.| |..:|:.|||::.|.|.|.
Mouse   442 GATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLILFGVLGLS 506

  Fly   502 AGLLSLLLPETHNKPMLETIADGERFG-KKTKA---DVYL--ETGQ 541
            ||.::||||||....:.|||.:.|..| :|:||   .:||  :||:
Mouse   507 AGAVTLLLPETKGVALPETIEEAENLGRRKSKAKENTIYLQVQTGK 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	180/530 (34%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	180/530 (34%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		3/3 (100%)