DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and Slc22a25

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_620263.1	Gene:	Slc22a25 / 192273	RGDID:	621104	Length:	552	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	156/565 - (27%)
Similarity:	277/565 - (49%)	Gaps:	60/565 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPF---------ENG 56
            |.:.:.:..:|..||:|.:....|.:.:|.::.|.|...|....|:.||.:|.         :||
  Rat     1 MAFQDLLNQVGSLGRFQILQMTFILIFNIIISPHSLLENFTAVIPNHRCWVPILDNDTVSGNDNG 65

  Fly    57 S-SYDLPTHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPR-SSNETKTC-SSYVYDRSKY 112
            : |.|   .|..:|.|     ..|:| .:....:...:|||:... :..:|:.| ..:|||:|.:
  Rat    66 NLSQD---DLLRVSIPLDSDLRPEKCRRFVQPQWDLLHLNGTFSSVTEPDTEPCVDGWVYDQSTF 127

  Fly   113 LNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGV 177
            |::.:|||:|||....:.:.:..||:.|:|:|:|::|.|:|::||:.||..:.:...:....|..
  Rat   128 LSTIITEWDLVCESQSLDSIAKFLFLTGILVGNILYGPLTDRFGRRLILICASLQMAVTETCAAF 192

  Fly   178 APEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHD 242
            ||.:..|...|.:.|.:.|.|...:.::.:|...|..:..|...::...::|..:.|..|:.|.:
  Rat   193 APTFLIYCSLRFLAGISFSTVLTNSALLIIEWTRPKFQALATGLLLCAGAIGQTVLAGLAFTVRN 257

  Fly   243 WRWLQIALTLPGLIFMFYYWIIP-----ESARWLLLKGRKDCAIANMQKAARFNKVEISDEALS- 301
            |..|.:|:::|     .::.::|     ||||||::..:....:..:.|.|..|.::.|.:.|:
  Rat   258 WHHLHLAMSVP-----IFFLLVPTRWLSESARWLIMTNKLQKGLKELIKVAHINGMKNSTDVLTI 317

  Fly   302 ELL-----DEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLI----FLDWLVTSGV 357
            |::     :|.|.|:.|:               |:||||..||||::..|:    |:.||..
  Rat   318 EVVRTIMKEELEASQTKS---------------SLWDLFRTPNLRKRICLLSLVRFVVWLSV--- 364

  Fly   358 YYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQ 422
             .||..|..:|..||.|...:.|.:.|||.:..:..:|..|||......:.:.|:|:||.:.:||
  Rat   365 -IGLLINFQHLRINVFLLQCLLGIITIPANLVGIFLVNHLGRRISQLFIISLFGISILAIIFVPQ 428

  Fly   423 RMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIW 487
            .|..|.:..|..|.:....|..:..:.:.|..||::|..|||...:.......::|....|.|..
  Rat   429 EMQILRMVLATFGGVFSFVSVSSALVHANELLPTIIRATALGVIGIAGSTGAALSPLFMILRTYS 493

  Fly   488 KPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTK 532
            ..||.:|.|.|:.:.||:.||||||.|:|:.::|.|.|..|:.::
  Rat   494 DSLPWIIYGVLSFLGGLVVLLLPETKNQPLPDSIQDVENEGRASR 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	151/541 (28%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	103/390 (26%)
Slc22a25	NP_620263.1	2A0119	11..525	CDD:273328	151/540 (28%)
		Aldolase_II	39..>85	CDD:294146	12/48 (25%)
		MFS	125..506	CDD:119392	111/404 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.940