DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and F45E10.2

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001022174.1	Gene:	F45E10.2 / 185801	WormBaseID:	WBGene00009729	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	537	Identity:	167/537 - (31%)
Similarity:	272/537 - (50%)	Gaps:	90/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGDFGRYQKIIYFLICLTSIPVAF---HKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWNLSYP 71
            ||.|||:|:|.:.|||   ||:||   |.::..|:::                           |
Worm    75 LGSFGRFQQIQFILIC---IPIAFVSMHVMSWTFVVS---------------------------P 109

  Fly    72 ENERCSYYDVDYTEEYLNGSIPRSSNETKT--CSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSD 134
            ..:.|:                 .:|||:.  |....|       ||...|.:.....::.||..
Worm   110 ARKICN-----------------ETNETRIDGCEELAY-------SASDRWEMDGDNGWIRATVQ 150

  Fly   135 SLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYTFARLMVGATTSGVF 199
            :::.:|.::||...|.::||.|||.:||..||:||:..:|..|||.::.|...:...|.|..|::
Worm   151 AVYFIGQMIGSFTCGVMADKIGRKKVLFWCLVLQVVCALLLIVAPTWWIYAILKAGTGFTQPGIY 215

  Fly   200 LVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWII 264
            .||.|:.:|:||...|.:..:...:|..:|.:|.||.|||:.|:|.|..::.:|.|||:.|||:|
Worm   216 GVAVVLGIELVGKKYRSFIAVIANVFGVIGGVLLAVMAYFIVDYRLLHASIAIPSLIFITYYWMI 280

  Fly   265 PESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPP 329
            .||||||:.:.:.|.|...:...|.:||..|.           :|..||.::|::.....:....
Worm   281 HESARWLVSQEKYDDANVVLCATANWNKKTIP-----------KNWAEKIEKKMDVTATKKKDSF 334

  Fly   330 SVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTL 394
            .|:||...|.:|::|:..|:.|.||:.:||||:..:...||::.:.||.|..:|:||.|.:.|.:
Worm   335 GVFDLIRTPQMRKRTIANFVMWPVTTMMYYGLTMRSDVGGGSLFVTFVTSQLMELPAVIIVALLI 399

  Fly   395 NRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLI-----VACAMLGKLAITASYGTVYIFSAEQF 454
            :|.|||.:..|.:..||:.|||:.:    .|.||     |...|:.|.|::.:|..:|.:::|.|
Worm   400 DRLGRRIMYSGAIFTAGMLLLASWL----THDLIPSQYAVIMLMVAKGAVSVAYTVMYTYTSELF 460

  Fly   455 PTVVRNVALGAASMVARISGMMAPFLNF-----LATIWKPLPLLICGSLTLVAGLLS-LLLPETH 513
            |||:||.|:|..|.:||...:.|.|:.|     ...|...:|..|   |.|.|.::| .:||||.
Worm   461 PTVIRNTAVGCCSTIARFGAISASFIAFFLVDRFGRIVMIIPFTI---LALCASIVSWTMLPETV 522

  Fly   514 NKPMLETIADGERFGKK 530
            |:.:.::|::.|  |.|
Worm   523 NQQLPDSISEVE--GNK 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	162/524 (31%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	130/385 (34%)
F45E10.2	NP_001022174.1	MFS_SLC22	121..518	CDD:340875	137/421 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I7320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80237
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.930