DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and oct-2

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_509899.3	Gene:	oct-2 / 181325	WormBaseID:	WBGene00003843	Length:	757	Species:	Caenorhabditis elegans

Alignment Length:	594	Identity:	176/594 - (29%)
Similarity:	288/594 - (48%)	Gaps:	66/594 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EAIIHL-GDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYD----LPTH 64
            |.|:.| |....:|.|:|.:|.:..:|.|...|:.|:::.:||..|.:||.|..|:.    ...:
Worm   157 EGILQLIGGCSYWQIIVYLIISVQQVPHAMFNLSVVYMMYQPDHWCKIPFFNEESFSAELGYTNY 221

  Fly    65 LWN------LSYP----------ENERCSYYDVDYTEEYLN-----------GSIPRSSNETKTC 102
            .|:      :::|          .:::|.|::.||....|:           |.|.|       |
Worm   222 TWDQVLNSTIAFPRTFNKQRNELHHDQCHYFERDYVHIKLSPWAQVKDMNATGKINR-------C 279

  Fly   103 SSYVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVI 167
            ..:.||.|....:.|||||.||..::..|.....:.||.|:|..|.|.:||:||||..:....::
Worm   280 KEWEYDTSVMDRTIVTEWNRVCDNNWSRAHVHMSYSLGYLVGCFVGGFISDRYGRKTAITGFGIL 344

  Fly   168 QVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFML 232
            .:|||.|...:.|:..:...|.::.||.....|.|||:.||:.|...|...|..:...::.|:..
Worm   345 TMLFGFLLTYSKEFEIFLVVRFLLAATNEAADLAAYVLCMEVTGTKYRSIVGSLIQAPWACGYAF 409

  Fly   233 TAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEI-S 296
            .|:.||....|..:.:...|..:|.:...:.:|||.|||:|..:...|...:::|..:||..: |
Worm   410 LALIAYLTKSWTMIHLICVLLHIISLMLLYFLPESPRWLILNNKTKQAEKIIREACHYNKSRLPS 474

  Fly   297 DEALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGL 361
            |..|.      .::|:|...|..::       ||.:.||....||.:.:::|:.|:.|:.||||:
Worm   475 DLGLV------RHAEKKKWMKHNEK-------PSYFHLFRSSELRFRNVVLFIVWIATALVYYGM 526

  Fly   362 SWNTSN--------LGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATV 418
            ....|:        ..||..||..::||:|:|..:|.:..| |.||:......|..:||.||.:|
Worm   527 VIALSDQSSPGRRVFDGNFFLNNAMAGAIELPTLVFCVFLL-RMGRKRSQMLVLFGSGLFLLTSV 590

  Fly   419 I-IPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNF 482
            : :.::..||.:...:|.|..|..|:..:|||::|..||||||.|:|.:|||||:....:.::..
Worm   591 VMVYRKQSTLALIFMLLSKACIQGSFNILYIFTSELNPTVVRNSAVGISSMVARMGAGASGYIAI 655

  Fly   483 LATIWKPL-PLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRA- 545
            |:.:..|| |:.|....:|:||.|.||||||...|:.:||.|..:..|:........:|..|..
Worm   656 LSDVTMPLVPMTIFACFSLLAGCLVLLLPETQGLPLPDTILDSVQMVKRNTKPCGTLSGTFLGGI 720

  Fly   546 -PEAQPLKG 553
             .:|||..|
Worm   721 DDDAQPYGG 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	163/550 (30%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	116/386 (30%)
oct-2	NP_509899.3	MFS_SLC22	281..673	CDD:340875	125/405 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850