DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and Y82E9BR.16

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001022960.1	Gene:	Y82E9BR.16 / 175300	WormBaseID:	WBGene00022348	Length:	575	Species:	Caenorhabditis elegans

Alignment Length:	614	Identity:	189/614 - (30%)
Similarity:	299/614 - (48%)	Gaps:	100/614 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAII-HLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLP-- 62
            |.:|:.:. :||:.|:||||.:||:||.:|.|:.|.|:..|......:||.||      .|||
Worm     1 MKFDDFLFTYLGEMGKYQKIQFFLVCLPTIVVSMHALSWTFASVDTPYRCRLP------SDLPEK 59

  Fly    63 ----THLWNLSYPENER------CSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAV 117
                |.|.|.:...|:.      ..|.....|..|...::|    :.:||..:::|.||...:||
Worm    60 EPYYTTLLNFTKCTNDADANVPISEYGKPGVTCHYDRCTLP----DNETCHEHIFDHSKVEYTAV 120

  Fly   118 TEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYF 182
            ..|.:.|.|.::.||..:.:.:|.:.||..||.|.|:.|||.:.|.::|||:....|..:||.::
Worm   121 QRWEITCDRSWIKATIQAAYYVGQMAGSTTFGMLGDRIGRKKVFFLAIVIQITCAYLIAIAPYWW 185

  Fly   183 TYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQ 247
            .|..||...|.:..|:|::|.|:.||:|||..|..|.:...:||::|.:...:.|.:..:::.|.
Worm   186 LYALARAGTGFSHPGIFVIAVVIGMELVGPKYRKLASVITGLFFALGQIFLGIEAIYFTNYQILH 250

  Fly   248 IALTLPGLIFMFY-----------------------------YWIIPESARWLLLKGRKDCAIAN 283
            :.:..|.|:|:.|                             .|::|||||||:.:.|...|...
Worm   251 VVIASPALLFLSYCQKSAKNRKKIDFANFLADFLLKNRFFFSRWLVPESARWLVSQKRYKEADEV 315

  Fly   284 MQKAARFNKVEISDEALSELLDEGENSEEKAKQKLEDQELDEGPPPSV-------WDLFCYPNLR 341
            :||||..|               |....|...::|:|.....|..|..       .|||..|.||
Worm   316 LQKAASVN---------------GTVLPENWWEQLDDSTTGGGGAPGAPTKKLTGADLFRTPELR 365

  Fly   342 RKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGC 406
            ::||::|..|.|.|.||||::...:.|||::.:||:.:..|||||...:.|.::|.|||.||.|.
Worm   366 KRTLVVFFLWPVISMVYYGMAMKANVLGGDIYVNFIFAAFVEIPALFIVYLLIDRIGRRLILAGG 430

  Fly   407 LVMAGLSLLATVIIPQRMHTLIVACAM-LGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVA 470
            |.:||..||...::...:...:....| ..|.:||..|..:|.:|.|.||||:||.|:|..|.:|
Worm   431 LFIAGACLLVNWLMGDNVQLWMAITQMAFTKGSITGVYAAIYTYSPELFPTVIRNTAMGFCSTIA 495

  Fly   471 RISGMMAPFLNFLATIW------KPLPLLICGSLTLVAGLLSLL-LPETHNKPMLETIADGERFG 528
            |:..:.|.::    ::|      |...::..|.:.::|.:::|| ||||..||:.|:|.:
Worm   496 RVGAIAASYI----SMWIAEQFGKVFMIIPFGCMAVLAAVMTLLFLPETMGKPLPESIEE----- 551

  Fly   529 KKTKADVYLETGQELRAP-EAQPLKGSGE 556
                    :|.|...|:. |.|||..|.|
Worm   552 --------IEEGDSYRSSHEMQPLSKSTE 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	175/564 (31%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	126/418 (30%)
Y82E9BR.16	NP_001022960.1	MFS_SLC22	107..537	CDD:340875	137/448 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I7320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80237
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48025
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.960