DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	579	Identity:	171/579 - (29%)
Similarity:	279/579 - (48%)	Gaps:	64/579 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EAIIH-LGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-FENGSSYDLPTH--- 64
            |.|:: :|....:|..||.||.|..||.|...|..|:::..|:|:|.:| |.:.:...:.:|
Worm   203 EGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSHGPY 267

  Fly    65 LW------NLSYP----------ENERCSYYDVDYTEEYLNGSIPRSSNET------------KT 101
            ||      |:|:.          :.:.|.:|:.. .|.|  ..:.|...||            |.
Worm   268 LWGVDDIKNISFVFPNANSDGAYQRDSCYFYERS-EERY--RQLRRMPLETAMSEAWKDVAPKKK 329

  Fly   102 CSSYVYDRSKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLV 166
            |.:|.:::...:.:.||::||||...|....:...:.:|.|||.::.|..|||.||||.:....:
Worm   330 CQAYHFEKDVMVETIVTDFNLVCDSWFAKGHAHMFYSIGYLLGCVLGGIASDKIGRKPTIIGFGI 394

  Fly   167 IQVLFGVLAGVAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFM 231
            :..:.||.......|..:...||:.........|.||.:.||:.|...|...|..:...:::|:.
Worm   395 LSSMLGVFLPFNDYYPMFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAMVGSMLQAPWALGYA 459

  Fly   232 LTAVFAYFVHDWRWLQIALTLPGLIFMFYYWI--IPESARWLLLKGRKDCAIANMQKAAR----- 289
            |.|:.||....|:.:|:...  ||.||...:|  ||||.|||:::.|...|...::||.|
Worm   460 LLALIAYLTKSWKTIQVIAA--GLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKACREPPFP 522

  Fly   290 FNKVEISD-EALSELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLV 353
            ||....|. ..|...|:...:.|.|..:|       .|......|||....||.:|:.:.:.::.
Worm   523 FNMCTTSKCGNLPSDLELVSHRERKLNKK-------NGGKIGFLDLFTMKELRYRTISVCIVFMA 580

  Fly   354 TSGVYYGL--SWNTSNLGGNVL------LNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMA 410
            |:.|||||  :.:..:..|..|      ||..|:||:|||. :|..:.:.:.||:..|...|:.:
Worm   581 TALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPT-LFACVWMMQLGRKKALMLTLITS 644

  Fly   411 GLSLLATVIIPQRMHTLIVACAM-LGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISG 474
            ||.::..::.....|.::....| .||:|:..::..:|||::|.:||||||.|:|..|||||...
Worm   645 GLFIIVAMLSMVSGHYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRNTAVGVTSMVARFGS 709

  Fly   475 MMAPFLNFLATIWKPL-PLLICGSLTLVAGLLSLLLPETHNKPMLETIADGERFGKKTK 532
            .::.::..|:.|..|: |::|....:|.||:|..:||||..||:.||:.|...|.:.||
Worm   710 GLSSYIALLSNISLPIVPMIIFAVFSLFAGMLVFVLPETSEKPLPETLDDAINFLEPTK 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	163/558 (29%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	116/393 (30%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	126/422 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163018
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850