Protein Alignment Orct2 and SLC22A31

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001371692.1
• Gene: SLC22A31 / 146429
• HGNCID: 27091
• Length: 446
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 129/448 - (28%)
• Similarity: 194/448 - (43%)
• Gaps: 85/448 - (18%)

  Fly   120 WNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTY 184
            ||||||..:.........:||.|||.::.|...|::||:.:..||||:....|....:|..:.|.
Human     9 WNLVCGDGWKVPLEQVSHLLGWLLGCVILGAGCDRFGRRAVFVASLVLTTGLGASEALAASFPTL 73

  Fly   185 TFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQ-I 248
            ...||:.|.|.:|..|..|:..:|:..|..||...:...:|..||.:|....|..|.|||.|| :
Human    74 LVLRLLHGGTLAGALLALYLARLELCDPPHRLAFSMGAGLFSVVGTLLLPGLAALVQDWRLLQGL 138

  Fly   249 ALTLPGLIFMFYYW--IIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSE 311
            ...:.||:.:|:.:  :.|||..|||..|:...|...:.:.|..:.|...|.:|.      |||.
Human   139 GALMSGLLLLFWGFPALFPESPCWLLATGQVARARKILWRFAEASGVGPGDSSLE------ENSL 197

  Fly   312 EKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVT--SGVYYGLSWNTSNLGGNVLL 374
            ......|..:.               |..|..:.|..|...||  :|:..|.|   |.:||.:..
Human   198 ATELTMLSARS---------------PQPRYHSPLGLLRTRVTWRNGLILGFS---SLVGGGIRA 244

  Fly   375 NFVISGAVEIP---------------AYIFLLLTLNRWGRRSI-LCGCLV--MAGLSLLA----- 416
            :|..|.|.::|               |.:|||||.:..|||.: |.|.:|  :|.|.|||
Human   245 SFRRSLAPQVPTFYLPYFLEAGLEAAALVFLLLTADCCGRRPVLLLGTMVTGLASLLLLAGAQYL 309

  Fly   417 ---TVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALG----------AASM 468
               ||:.          .::||.||..|......:|:||.||||:|...||          ||..
Human   310 PGWTVLF----------LSVLGLLASRAVSALSSLFAAEVFPTVIRGAGLGLVLGAGFLGQAAGP 364

  Fly   469 VARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIADGER 526
            :..:.|....||.          .::..||.::|.|..|||||:.::.:.:::.|.:|
Human   365 LDTLHGRQGFFLQ----------QVVFASLAVLALLCVLLLPESRSRGLPQSLQDADR 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	127/440 (29%)
SLC22A31	NP_001371692.1	MFS	9..383	CDD:475125	118/417 (28%)