Protein Alignment Orct2 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 167/571 - (29%)
• Similarity: 265/571 - (46%)
• Gaps: 65/571 - (11%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDL---- 61
            |.:.|.:..:|..||:|.:....:.::.:.:....:...|..|.|..||..|..:.|:...
Human     1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILG 65

  Fly    62 ---PTHLWNLSYP--ENER---CSYY--------DVDYTEEYLNGSIPRSSNETKTC-SSYVYDR 109
               |..|..:|.|  .|:|   |..:        |.:.|      :...|..:|:.| ..:||||
Human    66 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNAT------ATSWSEADTEPCVDGWVYDR 124

  Fly   110 SKYLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVL 174
            |.:.::.|.:|||||....:...:.|:::.|:|:|:...|..||::||:.:|..|.:...:.|..
Human   125 SIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTA 189

  Fly   175 AGVAPEYFTYTFARLMVGATTSGVFL-------------------------VAYVVAMEMVGPDK 214
            |..||.:..|...|.::....:||.:                         :..:..||......
Human   190 AAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAARA 254

  Fly   215 RLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDC 279
            |........:.||.|..|||..||.|.||..||:.:::|..:...|.|.:.|||||||..||.|.
Human   255 RPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDW 319

  Fly   280 AIANMQKAARFN-KVEISDEALSELLDEGENSEEKAKQKLEDQELDEG-PPPSVWDLFCYPNLRR 342
            .:..:.:.|..| |..:.|....|:|.....           :||..| ||.|:..|...|.||.
Human   320 GLQELWRVAAINGKGAVQDTLTPEVLLSAMR-----------EELSMGQPPASLGTLLRMPGLRF 373

  Fly   343 KTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCL 407
            :|.:..|.|......::||:.:...||.|:.|..:..|.|:|||.:..||.|:..|||..|...|
Human   374 RTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASL 438

  Fly   408 VMAGLSLLATVIIPQRMHTLIVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARI 472
            ::|||.:||..::|..|..|..|.|:||...:.|::..:.|:|:|.||||:|..|:|...|.||.
Human   439 LLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG 503

  Fly   473 SGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSLLLPETHNKPMLETIAD 523
            ..::.|.:..|......||||:.|::.:::||.:||||||.:.|:.:||.|
Human   504 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	162/556 (29%)
		MFS	127..503	CDD:119392	119/402 (30%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	162/556 (29%)
		MFS	122..541	CDD:119392	133/429 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153241
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.980