Protein Alignment Orct2 and SLC22A9

DIOPT Version :9

• Sequence 1: NP_001262907.1
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_543142.2
• Gene: SLC22A9 / 114571
• HGNCID: 16261
• Length: 553
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 153/551 - (27%)
• Similarity: 263/551 - (47%)
• Gaps: 49/551 - (8%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALP-FENGSSYDLPT- 63
            |.:.:.:.|.||..|:|.:....:.:.::....|.:...|....|..||.:. .:|.:..|..|
Human     1 MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTG 65

  Fly    64 -----HLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTC-SSYVYDRSKYLNS 115
                 .|..:|.|     ..|:| .:....:...:|||:.|.:|: :.:.| ..:||||..:.::
Human    66 ALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSST 130

  Fly   116 AVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPE 180
            .||||:|||....:.:.:..:||.|:::|.|:.|.|||::||:.:|....:...:.|..|.:||.
Human   131 IVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPT 195

  Fly   181 YFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYA----------GIFVMMFFS-VGFMLTA 234
            :..|...|.:.|           :.||.::.....|.|          ||.:.|..| :.||..|
Human   196 FLIYCSLRFLSG-----------IAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLA 249

  Fly   235 VFAYFVHDWRWLQIALTLP-GLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDE 298
            ..|:.:.||..||:.:::| .:||:...|:: ||||||::..:.:..:..::|||..:.::.:.:
Human   250 GLAFAIRDWHILQLVVSVPYFVIFLTSSWLL-ESARWLIINNKPEEGLKELRKAAHRSGMKNARD 313

  Fly   299 ALS-ELLDEGENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLS 362
            .|: |:|......|.:|.||.:         ||:.::...||:.::..|:..........|:||:
Human   314 TLTLEILKSTMKKELEAAQKKK---------PSLCEMLHMPNICKRISLLSFTRFANFMAYFGLN 369

  Fly   363 WNTSNLGGNVLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTL 427
            .:..:||.||.|...:.|||.:.|.......|....||:.....:.:..:.|||.:.:||.|.||
Human   370 LHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTL 434

  Fly   428 IVACAMLGKLAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPL 492
            ....|.||..|...:....:....|..||::|..|:|..:..|.|:|.:||.:..|:....|||.
Human   435 REVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPW 499

  Fly   493 LICGSLTLVAGLLSLLLPETHNKPMLETIAD 523
            :|.|....::|...||||||.|||:.:||.|
Human   500 IIYGVFPFISGFAFLLLPETRNKPLFDTIQD 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	148/536 (28%)
		MFS	127..503	CDD:119392	104/388 (27%)
SLC22A9	NP_543142.2	Sugar_tr	11..527	CDD:331684	148/536 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	528..553		2/3 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153499
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940