Protein Alignment Orct2 and SLC22A7

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_011512558.1
• Gene: SLC22A7 / 10864
• HGNCID: 10971
• Length: 610
• Species: Homo sapiens
• Alignment Length: 630
• Identity: 176/630 - (27%)
• Similarity: 279/630 - (44%)
• Gaps: 102/630 - (16%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPF--ENGSSYD--L 61
            ||::|.:..:|.||.:|.....|:.|..:.:..|.|..:||.|.|..|||||.  .|.|..|  |
Human     1 MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWL 65

  Fly    62 PTHLWNLSYPENERCSYYDVDYTEEYLN---GSIPRSSNE------TKTCS-SYVYDRSKYLNSA 116
            ..||  ...|:....|.....|.:...|   |...:|..|      |..|| .:.||.|::.::.
Human    66 EAHL--PREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTI 128

  Fly   117 VT-------------------------------------------------------------EW 120
            .|                                                             ||
Human   129 ATESQVGIYIIHLEVECRWRQSPWEAAGRGLPWEEAEAAGLGRDKVSYSPSWRESLGGLLSGMEW 193

  Fly   121 NLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFTYT 185
            :|||.:..:...:.:.|..|||:|::.||.|||::||:.:|..:.|..::.|:.:..:..|..:.
Human   194 DLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFA 258

  Fly   186 FARLMVGATTSGVFLVAYVVA---MEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQ 247
            ..|.:.|:..:|..::...:.   :|.:..:.|..||:....|::.|.||.|:..|.:.|||||.
Human   259 ITRTLTGSALAGFTIIVMPLGEAELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLL 323

  Fly   248 IALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGENSEE 312
            :|:|||....:...|.:||||||||.:|....|...:...||.|...:.:::.|:.......:.|
Human   324 LAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGE 388

  Fly   313 KAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFV 377
            :..::           ||..|||..|.||..:|...:.|...:..|||||.:.|.||.||....:
Human   389 RVVRR-----------PSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQL 442

  Fly   378 ISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITAS 442
            :.||||:|:.:.:.|::...|||....|.|:...|:....:::...|.:.....|::||....|:
Human   443 LFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAA 507

  Fly   443 YGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSL 507
            :.|.|:|::|.:|||:|...:|..::|.|:.|.:||....|..:|..||.|..|.:.|:|...:|
Human   508 FTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTAL 572

  Fly   508 LLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLK 552
            |||||....:.|||.|.||....|..       ||    |..|:|
Human   573 LLPETRQAQLPETIQDVERKSAPTSL-------QE----EEMPMK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	161/586 (27%)
SLC22A7	XP_011512558.1	MFS	106..563	CDD:475125	123/467 (26%)