DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and slc22a13

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_031760340.1	Gene:	slc22a13 / 100491580	XenbaseID:	XB-GENE-959647	Length:	547	Species:	Xenopus tropicalis

Alignment Length:	588	Identity:	195/588 - (33%)
Similarity:	307/588 - (52%)	Gaps:	80/588 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPTHLWN 67
            :.|.:.::|:|||:||.:..::.|.|...|||..:.||:......||      .|.:.|   |.|
Frog     4 FAEILKNVGEFGRFQKQLVVVLSLLSFLNAFHMFSQVFMEIPVPHRC------DSRWIL---LIN 59

  Fly    68 LSYPENERCSY--------------------YDVDYTEEYLNGSIPRSSNETKTC-SSYVYDRSK 111
            .:..|.||.:|                    :|::..|::       ..|.|..| ..:.||.|:
Frog    60 PNLTEAERLNYTIPRDGRGQYEQCLMYSPVQWDMESIEKF-------GLNSTGPCQDGWEYDTSE 117

  Fly   112 YLNSAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAG 176
            ..::.||:::|||.|......|.|::|.|:|:|:::||.|.|:.||:|::..|:::|::||:.|.
Frog   118 QKSTLVTQFDLVCHRREQTGISQSVYMSGLLIGALLFGPLGDRIGRRPVILLSMLLQLVFGLSAA 182

  Fly   177 VAPEYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVH 241
            .||.::.||..|.:||.:.||:.:...|:..|.||..:|..|.|...:.|:||.|..|..:|.:.
Frog   183 FAPHFYVYTAFRWVVGTSMSGLMINNLVLGAEWVGSSRRACATITAHVCFAVGLMALAGVSYGIR 247

  Fly   242 DWRWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDE 306
            :||.|||..:.|..:..||.|::||||||||.||:|:.|:..::|||..||.||.::.|.:.
Frog   248 NWRLLQIVSSAPTALLFFYIWVLPESARWLLTKGKKEKAVKLLKKAAAMNKKEIPEDLLFQF--- 309

  Fly   307 GENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGN 371
               :|||:.:.           .::.|||....||:.||::.|.|.|.|.||||||.|..:.|.:
Frog   310 ---NEEKSPKS-----------GNMIDLFRNKTLRKLTLVMCLVWFVNSLVYYGLSLNVGSFGLD 360

  Fly   372 VLLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGK 436
            :.|..::.|||||||.|..:..:..:||:.....||.:.|...|....||:.:...|...|::||
Frog   361 IYLTQLVFGAVEIPARIGAMFAVQLFGRKPSQMFCLFLGGTVCLIITAIPRNLPIAITILAVIGK 425

  Fly   437 LAITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLV 501
            .:|.:|:...||::||.||||:|...:|.|||.||::|:.||.::.|......:|:.|.||..::
Frog   426 FSIASSFSICYIYAAEVFPTVIRQNGVGLASMAARVAGITAPLISLLDKYHAAIPMAIYGSGPII 490

  Fly   502 AGLLSLLLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETNGSTIANG- 565
            .|:|..|||||.||                  |:...|.|:      :|:|.|....|..:.||
Frog   491 GGILCFLLPETRNK------------------DLQDHTQQD------EPIKSSNTLPGERLINGV 531

  Fly   566 -HK 567
             ||
Frog   532 DHK 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	183/529 (35%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	137/375 (37%)
slc22a13	XP_031760340.1	2A0119	12..509	CDD:273328	184/547 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1443
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		mtm14089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920