DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and slc22a8

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	571	Identity:	176/571 - (30%)
Similarity:	285/571 - (49%)	Gaps:	34/571 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDL---- 61
            |.:.|.:...|..||:|.....|:|...:.:|.|.|...|..|.||.:|.   .|.:.|..
Frog     1 MSFAELLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCK---ANDTGYQSNSTD 62

  Fly    62 PTHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTCS-SYVYDRSKYLNSAVT 118
            .|....||.|     :.:|| .|.::.:.....|.:...||. .|:.|: .:.|.:.::.::.:|
Frog    63 ETGYERLSAPLDANGQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPCTIGWEYSKDEFSSTIIT 127

  Fly   119 EWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFT 183
            ||:|||||......:.|::|.|||:|:|:.|.|||:|||:.:|..|.....:.||.|..:|.|.:
Frog   128 EWDLVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAVSGVCAAFSPNYLS 192

  Fly   184 YTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQI 248
            |...|.:.|...||:.|....:.:|.|....|...|......::.|.:|.|..||.:.||||||:
Frog   193 YCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTVTGTLAGFSYTAGQLLLAGLAYGMRDWRWLQL 257

  Fly   249 ALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGEN-SEE 312
            .::||..|:..|.|..|||||||:|.|:.:.|:..::|.|..|..:          :|||. :.|
Frog   258 CVSLPFFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKK----------EEGEKITLE 312

  Fly   313 KAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFV 377
            ..|.::..:........||.||.....:||.:..:.|.|..||..||||:.:......::.|..|
Frog   313 SLKSEMIKELASAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQV 377

  Fly   378 ISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITAS 442
            |.|||:.||.:.....:...||:......|::.|::::|.:.:|..:.|:..:.|:.||..:.||
Frog   378 IFGAVDFPAKLVSATAMIYVGRKFTQFMSLILGGIAIIANIFVPNELQTVRTSLAVFGKGCLAAS 442

  Fly   443 YGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSL 507
            :..:::::.|.:|||:|...||..|.:|||.|::||.:..|..::..:||||.|...:::||...
Frog   443 FSCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGLCVF 507

  Fly   508 LLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETN 558
            .||||.|||:.:||.:.|:.....|        :|:...|...||...:.|
Frog   508 FLPETVNKPLPDTIEEVEKGINAPK--------KEIEKNEMDSLKRGMKEN 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	165/521 (32%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	119/376 (32%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	132/414 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.140