Protein Alignment Orct2 and slc22a8

DIOPT Version :10

• Sequence 1: NP_651238.2
• Gene: Orct2 / 42890
• FlyBaseID: FBgn0086365
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_002937554.2
• Gene: slc22a8 / 100490266
• XenbaseID: XB-GENE-22061134
• Length: 556
• Species: Xenopus tropicalis
• Alignment Length: 571
• Identity: 176/571 - (30%)
• Similarity: 285/571 - (49%)
• Gaps: 34/571 - (5%)

  Fly     1 MGYDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDL---- 61
            |.:.|.:...|..||:|.....|:|...:.:|.|.|...|..|.||.:|.   .|.:.|..
 Frog     1 MSFAELLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCK---ANDTGYQSNSTD 62

  Fly    62 PTHLWNLSYP-----ENERC-SYYDVDYTEEYLNGSIPRSSN-ETKTCS-SYVYDRSKYLNSAVT 118
            .|....||.|     :.:|| .|.::.:.....|.:...||. .|:.|: .:.|.:.::.::.:|
 Frog    63 ETGYERLSAPLDANGQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPCTIGWEYSKDEFSSTIIT 127

  Fly   119 EWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPEYFT 183
            ||:|||||......:.|::|.|||:|:|:.|.|||:|||:.:|..|.....:.||.|..:|.|.:
 Frog   128 EWDLVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAVSGVCAAFSPNYLS 192

  Fly   184 YTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRWLQI 248
            |...|.:.|...||:.|....:.:|.|....|...|......::.|.:|.|..||.:.||||||:
 Frog   193 YCIFRFLTGMALSGIGLNTTALIVEWVPTRVRTVTGTLAGFSYTAGQLLLAGLAYGMRDWRWLQL 257

  Fly   249 ALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGEN-SEE 312
            .::||..|:..|.|..|||||||:|.|:.:.|:..::|.|..|..:          :|||. :.|
 Frog   258 CVSLPFFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKK----------EEGEKITLE 312

  Fly   313 KAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVLLNFV 377
            ..|.::..:........||.||.....:||.:..:.|.|..||..||||:.:......::.|..|
 Frog   313 SLKSEMIKELASAKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQV 377

  Fly   378 ISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLAITAS 442
            |.|||:.||.:.....:...||:......|::.|::::|.:.:|..:.|:..:.|:.||..:.||
 Frog   378 IFGAVDFPAKLVSATAMIYVGRKFTQFMSLILGGIAIIANIFVPNELQTVRTSLAVFGKGCLAAS 442

  Fly   443 YGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAGLLSL 507
            :..:::::.|.:|||:|...||..|.:|||.|::||.:..|..::..:||||.|...:::||...
 Frog   443 FSCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGLCVF 507

  Fly   508 LLPETHNKPMLETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGETN 558
            .||||.|||:.:||.:.|:.....|        :|:...|...||...:.|
 Frog   508 FLPETVNKPLPDTIEEVEKGINAPK--------KEIEKNEMDSLKRGMKEN 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_651238.2	2A0119	11..520	CDD:273328	165/521 (32%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	132/414 (32%)