DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct2 and slc22a16

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_002936981.2	Gene:	slc22a16 / 100488673	XenbaseID:	XB-GENE-961385	Length:	567	Species:	Xenopus tropicalis

Alignment Length:	550	Identity:	182/550 - (33%)
Similarity:	298/550 - (54%)	Gaps:	43/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 HLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRCALPFENGSSYDLPT-------HLW 66
            ::|.|||:|.:|||.....:|....|.||.||:...|.|.|..| ||.||..||.       .:|
Frog     7 YVGHFGRFQALIYFSSAFQAISCGIHYLASVFIAITPKFICRAP-ENISSVLLPNASTLRLEDVW 70

  Fly    67 NLSYP--------------ENERCSYYDVDYTEEYLNGSIPRSSNETK-TCSS-YVYDRSKYLNS 115
            .|..|              |..:||.:..:.| .||..|.  ..|:|. :||: |.||.:...:|
Frog    71 ELWTPKDYLVVKQENGDIWELNQCSRFKRENT-SYLTYSY--DGNKTLFSCSNGYYYDNTNLESS 132

  Fly   116 AVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAPE 180
            .||:|:|||.|:::|......||.|||:|:::||.::|:.||:.||:.:...|.|||:......:
Frog   133 IVTDWHLVCEREWLAKLIQPTFMFGVLIGAVIFGDIADRVGRRLILWLTSTGQFLFGIAVAFTFD 197

  Fly   181 YFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKRLYAGIFVMMFFSVGFMLTAVFAYFVHDWRW 245
            |:::...|.::...:||.::|.:|...|.||...|.:|.:.|..||:||.|:.::..:.|..|..
Frog   198 YYSFVIVRFLLAMVSSGYYVVVFVYVTEYVGIKARSWASMHVHAFFAVGVMIVSLVGFLVRTWWM 262

  Fly   246 LQIALTLPGLIFMFYYWIIPESARWLLLKGRK---DCAIANMQKAARFNKVEISDEALSELLDEG 307
            .||.|:|..|.|:...|::||:..||..:|:.   :..|..::|   :||:....: ||||.
Frog   263 YQIILSLTTLPFVLCCWMLPETPFWLYSQGKHKEVEKLIGTIEK---WNKISTPCK-LSELC--- 320

  Fly   308 ENSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNV 372
                  :.|:.:..|:|.....||.|||...:..|:|:.::|.|...|..||..:.|:.|||||.
Frog   321 ------SVQETQKTEMDTLKKHSVLDLFYNWSFARRTVTVWLIWFTGSLGYYVFALNSVNLGGNE 379

  Fly   373 LLNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKL 437
            .||..::.|||||:||.....:::.|||:.|...|:::.:.....::|||...|:.:|.:|.||.
Frog   380 YLNLFLTSAVEIPSYIVACFGMDKIGRRNTLAPFLILSAVICGIIMLIPQDHSTVTIAMSMGGKF 444

  Fly   438 AITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVA 502
            :|..::|.:|:::||.:||:||::|:|:.||:.||..::|||..:|..:|..:|.::.|.:..:.
Frog   445 SIAVAFGLIYLYTAELYPTIVRSLAVGSGSMMCRIGSVVAPFCVYLTDVWIFMPQMLVGIMAFLT 509

  Fly   503 GLLSLLLPETHNKPMLETIADGERFGKKTK 532
            |:|:|.||||...|:..||.:....|...:
Frog   510 GVLTLKLPETLGVPLTSTIEEAAEMGTNNR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	179/534 (34%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	122/378 (32%)
slc22a16	XP_002936981.2	MFS_SLC22A16_CT2	111..517	CDD:340933	140/418 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010