DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct2 and slc22a5

DIOPT Version :9

Sequence 1:	NP_001262907.1	Gene:	Orct2 / 42890	FlyBaseID:	FBgn0086365	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	576	Identity:	190/576 - (32%)
Similarity:	281/576 - (48%)	Gaps:	54/576 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG-YDEAIIHLGDFGRYQKIIYFLICLTSIPVAFHKLAGVFLLAKPDFRC-------------AL 51
            || |||....||..|.:...::.|:.|..|....|.|..||:.|.|..||             :.
Zfish     1 MGNYDEDTAFLGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHRCRVDVNLTEDWLEASA 65

  Fly    52 PFENGSSYDLP-THLWNLSYPENERCSYYDVDYTEEYLN-GSIPRSSNETKTCSSYVYDRSKYLN 114
            |.|..|:.||. :..|..|.......|  ...|:...:| ..|||...|    ..:||....|.:
Zfish    66 PTETLSNGDLQVSQCWRYSLQTLTNLS--GQGYSPGQINITDIPRERCE----DGWVYSADVYHS 124

  Fly   115 SAVTEWNLVCGRDFMAATSDSLFMLGVLLGSIVFGQLSDKYGRKPILFASLVIQVLFGVLAGVAP 179
            :.|:||:|||..::....:.|...:|.||||||.|||||::|||.:||.||..:.|.......:|
Zfish   125 TIVSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAAEALLMFAQSFSP 189

  Fly   180 EYFTYTFARLMVGATTSGVFLVAYVVAMEMVGPDKR-LYAGIFVMMFFSVGFMLTAVFAYFVHDW 243
            .:..:......:||....:::.|:|:..|::....| |:..:...:.:.||:||....|:.:..|
Zfish   190 SWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLGAFLHYCVGYMLLPWVAFAIRHW 254

  Fly   244 RWLQIALTLPGLIFMFYYWIIPESARWLLLKGRKDCAIANMQKAARFNKVEISDEALSELLDEGE 308
            |.|...|:...::::..:|:||||.||||.:|....:.|.::.|||.|:|     ...|::.:..
Zfish   255 RTLLRVLSGLTVVYIPLWWLIPESPRWLLSQGHVQESEAILRDAARKNRV-----PAPEVIFKQS 314

  Fly   309 NSEEKAKQKLEDQELDEGPPPSVWDLFCYPNLRRKTLLIFLDWLVTSGVYYGLSWNTSNLGGNVL 373
            ..:|.|.||.:...|         |:....|:||.|.:..|.|:..:..|:|||.||:||.|:..
Zfish   315 QIKEAAFQKSKYSAL---------DVLRTSNIRRTTFMCLLLWMAINIGYFGLSLNTTNLSGDPF 370

  Fly   374 LNFVISGAVEIPAYIFLLLTLNRWGRRSILCGCLVMAGLSLLATVIIPQRMHTLIVACAMLGKLA 438
            ||..:|...|:||||.....|....||.:|...||:.|..||...:||.|:.||.:|..|.||..
Zfish   371 LNCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGFLLLVQLIPDRLQTLALALEMAGKFG 435

  Fly   439 ITASYGTVYIFSAEQFPTVVRNVALGAASMVARISGMMAPFLNFLATIWKPLPLLICGSLTLVAG 503
            .|.|:..|||::||.:|||:||:.:|..|..|||..:.||::.||.|..:.||.::.||||:.|.
Zfish   436 FTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGSLTITAS 500

  Fly   504 LLSLLLPETHNKPM---LETIADGERFGKKTKADVYLETGQELRAPEAQPLKGSGE 556
            |.:|.||||..|.:   ||.:.....|..:.|..|  |.|            |.||
Zfish   501 LANLFLPETFGKVLPENLEQMQKSRSFPGRDKQSV--EDG------------GGGE 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct2	NP_001262907.1	2A0119	11..520	CDD:273328	175/527 (33%)
Orct2	NP_001262907.1	MFS	127..503	CDD:119392	130/376 (35%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	174/523 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100389
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840