Protein Alignment jar and MYO1

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1405
• Identity: 399/1405 - (28%)
• Similarity: 640/1405 - (45%)
• Gaps: 339/1405 - (24%)

  Fly     7 LVWVRDAAEGYIQGRI--TEIGAKEFE--------VTPTDRK-------------YPKRTCHFDD 48
            :||:.|..|.:::|.:  |:|...:|.        |.|.|..             :|.....||.
Yeast    12 IVWIPDEKEVFVKGELMSTDINKNKFTGQEEQIGIVHPLDSTEVSNLVQVRISDVFPVNPSTFDK 76

  Fly    49 IHSSCDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIK 113
            :          ::..||..|||.:.|.||:.||..|.||||....|:|:|||..: .||:.|.|.
Yeast    77 V----------ENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNL-NLYSEDHIN 130

  Fly   114 KYNGR------------SLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLK 166
            .|:.:            |..:||||:||||::|..::......|||:|:|||||||||:||.:|:
Yeast   131 LYHNKHNRLSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQ 195

  Fly   167 YLCYSHDSAGP--------------IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAK 217
            ||. |..|..|              .|.|||.:||:||:||||:|.||||||||||||::.::..
Yeast   196 YLA-SITSGSPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEH 259

  Fly   218 CQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGA-PQQLRD-KLSLGKPDDYRYLSGCTQY 280
            ..:.|.:|..||||||||..|:::|||||:||.||:|. ..:|:: :|......||:.||...|
Yeast   260 GMINGAHIEWYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQ- 323

  Fly   281 FANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLH 345
                   .:|||                 |:|.::|..|..||..:|.|..:...|:.:||.:|.
Yeast   324 -------DIIPG-----------------INDVENFKELLSALNIIGFSKDQIRWIFQVVAIILL 364

  Fly   346 LGNIAFEEIPDDVRGGCQVSEASEQS-----LTITSGLLGVDQTELRTALV--------SRVMQS 397
            :|||.|            ||:.:||:     ::.....||||:.:.:||::        ..|.||
Yeast   365 IGNIEF------------VSDRAEQASFKNDVSAICSNLGVDEKDFQTAILRPRSKAGKEWVSQS 417

  Fly   398 KGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQASNF-YIGVLDIAGFE 461
            |..             .:|....:||::.:|.|||..||.:||:::...::.. |||:|||||||
Yeast   418 KNS-------------QQAKFILNALSRNLYERLFGYIVDMINKNLDHGSATLNYIGLLDIAGFE 469

  Fly   462 YFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITF-TDNQDIIELIEAKS--N 523
            .|..|||||.||||.|||||:|||:::...||..|.:|.:....|.: .|.|..|:|||:|.  .
Yeast   470 IFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTIDLIESKGPPT 534

  Fly   524 GIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCY 588
            |:..|||||:.|||.:...|.:::..:|..:       ||:.|..|.   :.||:::|:||.|.|
Yeast   535 GVLPLLDEEAVLPKSTDESFYSKLISTWDQN-------SSKFKRSRL---KNGFILKHYAGDVEY 589

  Fly   589 NTEQFIEKNNDALHASLEGLVQECDNPLLQTLF-PSG---SSTSVRGKLN------------FIS 637
            ..|.::.||.|.|:.:|..|:....|.::..|| |.|   ||..|...::            |.:
Yeast   590 TVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVKKSARTSTFKT 654

  Fly   638 VGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPS 702
            ..|:.:.|...|:.:|.....:|:|||.||:....:.|...|.|.||:|:|.:..:.|...|||:
Yeast   655 TSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEGIRLAREGYPN 719

  Fly   703 RVLFADLYSMYKSVLPPELVSLPARTF-----------CEAMFQSLNLSAKDFKFGITKVFFRPG 756
            |:.|.:.:..|: :|.||  :....||           ||.:..||.|..|.:|.|.||:||:.|
Yeast   720 RIAFQEFFQRYR-ILYPE--NSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNTKLFFKAG 781

  Fly   757 KFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARG 821
                           :||.:.|.|.                 :||.|.:|.....:       ||
Yeast   782 ---------------VLADLEKQKD-----------------VKLNNIMIKLTATI-------RG 807

  Fly   822 FLARKQHRPRYQGIGKINKIRT--NTLKTIEIASGLKMGREE-----------IISGVNDIYR-- 871
            :..||:.....|   |:.|.|.  ||.:...     ::.:|:           :::..||:.|
Yeast   808 YTVRKEITYHLQ---KLKKTRVIGNTFRLYN-----RLVKEDPWFNLFIRIKPLLTSSNDMTRTK 864

  Fly   872 QIDDAIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQA--EEQERLRKIQEALEA 934
            :.::.|.|:|.:    .:||:|. ...:...|:.||:   :|:..|..  :|:|.|||.:..|..
Yeast   865 KFNEQINKLKND----LQEMESK-KKFLEEKNQKTVN---ELENTQDLLNQEKENLRKNESLLNR 921

  Fly   935 ERAAKEAEEQR------QREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAK 993
            .:.:.|..:::      :::||..::|:..........:.|.|::...:|.|.|   |:|..:..
Yeast   922 VKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAHQKIQGLQETIREREATL---EKLHSKNN 983

  Fly   994 DDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVS----- 1053
            :..|....|..:....:.:..|..||..::|:....:::.:|...    .::.||:..:|
Yeast   984 ELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVINSKE----EEIKSFNDKLSSSEED 1044

  Fly  1054 ------------NIASRYL-----------NKSENVRAQQQALGKQ----KYDLSKWK------- 1084
                        |||...|           :|:||.:.::.||..|    :.:|.|.|
Yeast  1045 LDIKLVTLEKNCNIAMSRLQSLVTENSDLRSKNENFKKEKAALNNQLKNKESELLKMKEKIDNHK 1109

  Fly  1085 -----YSELR-DAINTSCDI--ELLEACRQ--EF---HRRLKVYHAWKAKNRKRTTMDENERAPR 1136
                 :|:.| ||::....|  ||.|...|  |:   ::::|..::    |.:|.|.::.::...
Yeast  1110 KELATFSKQRDDAVSEHGKITAELKETRIQLTEYKSNYQKIKEEYS----NFQRETKEQEQKKRN 1170

  Fly  1137 SVMEAA--FKQPPLVQPI-QEIVTAQHRYFRIPFMRANAPD----NTKRGLWYAHFDGQWIARQM 1194
            |::|:.  .|...|...: |||...|:...||   ..|:.:    :|:|...|:
Yeast  1171 SLVESLNDSKIKELEARLSQEISLNQYLNKRI---SGNSVETNISSTRRSTSYS----------- 1221

  Fly  1195 ELHADKPPILLVAGTDDMQMCELSLEETGLTRKRGAEILE 1234
            :...||..|:       .:..:|.|..|.:||....||.|
Yeast  1222 DDPLDKEDII-------KKYYDLQLAFTEITRNLENEIEE 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	14/64 (22%)
		MYSc_Myo6	71..754	CDD:276833	266/754 (35%)
		CBD_MYO6-like	765..913	CDD:409646	31/162 (19%)
		ERM_helical	<954..1020	CDD:466641	12/65 (18%)
		MYO6_MIU_linker	1002..1093	CDD:480843	26/135 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	15/63 (24%)
		Myosin-VI_CBD	1160..1246	CDD:465157	17/79 (22%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	399/1405 (28%)
		Smc	1607..>1901	CDD:440809