Protein Alignment jar and MYO3

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_012793.2
• Gene: MYO3 / 853729
• SGDID: S000001612
• Length: 1272
• Species: Saccharomyces cerevisiae
• Alignment Length: 1089
• Identity: 316/1089 - (29%)
• Similarity: 489/1089 - (44%)
• Gaps: 195/1089 - (17%)

  Fly    65 LMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFA 129
            |..:::.:..:|||.|:....||||:.::||:|||:|:: .:|....::.|.|::..|:||||||
Yeast    44 LSKISDESINENLKKRFKNGIIYTYIGHVLISVNPFRDL-GIYTNAVLESYKGKNRLEVPPHVFA 107

  Fly   130 IADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLC---YSH-DSAGPIETKILDANPVLE 190
            ||:....:::.|..:|.:|:||||||||||:.|.:::|:.   .|| :|.|.|:..:|..||:||
Yeast   108 IAESMYYNLKSYNENQCVIISGESGAGKTEAAKRIMQYIAAASNSHSESIGKIKDMVLATNPLLE 172

  Fly   191 AFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGA 255
            :||.|||.|||||||.||::|:.::::.:...|.|::|||||.|:..|...|||:|:||....||
Yeast   173 SFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAGNITNYLLEKQRVVGQIKNERNFHIFYQFTKGA 237

  Fly   256 PQQLRDKLSLGKPDDYRY--LSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHN 318
            ....:....:..|:.|.|  .:|||    .|.|                       |||.:.:..
Yeast   238 SDTYKQMFGVQMPEQYIYTAAAGCT----TADT-----------------------IDDVKDYEG 275

  Fly   319 LDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQ 383
            ..:|:..:||...|:..|:.::||:|.:|||:|.|   :..|..||.:.|...  ..:.||.||.
Yeast   276 TLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIE---NEEGNAQVGDTSVTD--FVAYLLQVDA 335

  Fly   384 TELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI-PFQA 447
            :.|...||.|:||:..|..:|:|..|||...:|:..|||||||||:.|||.||..:|.|: .|..
Yeast   336 SLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQAFPG 400

  Fly   448 SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQ 512
            ::..||:|||.|||.|..|||||.||||.|||||:.|....||.|||.|:||.:....|.:.||:
Yeast   401 ADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKYFDNK 465

  Fly   513 DIIELIEAKS-NGIFTLLDEESKLPKPSYSHFTAEVHKSWANH---YRLGLPRSS---RLKAHRT 570
            .:.:|||||: .||...:::         |..||....:.|:.   .||.|..|:   .|:|::
Yeast   466 VVCDLIEAKNPPGILAAMND---------SIATAHADSNAADQAFAQRLNLFNSNPYFELRANK- 520

  Fly   571 LRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNF 635
                  |:::|:||.|.|:.....:||.|.|...|..|:....|..|.|:||  .......|...
Yeast   521 ------FVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFP--DDVDKDSKRRP 577

  Fly   636 ISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGY 700
            .:.|.|......||:|.|.:...::||.||||.......::....|.|:|..|....:.:...|:
Yeast   578 PTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGF 642

  Fly   701 PSRVLFADLYSMYKSVLPP--------------ELVSLPARTFCEAMFQSLNLSAKDFKFGITKV 751
            ..|..|......:..:.|.              |.|.|..|   :||     :..|:|:.|:|.|
Yeast   643 AYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILR---DAM-----IPEKEFQLGVTSV 699

  Fly   752 FFR-PGKFVEFDRIMRSDPENMLAIVAKV-KKWLIR--------SRWVKSALGALCVIKLRNRII 806
            |.: |......:.:......||.|.:.:. :::|.|        .|.::...|....:|||:
Yeast   700 FIKTPESLFALEDMRDKYWYNMAARIQRAWRRFLQRRIDAAIKIQRTIREKKGGNKYVKLRD--- 761

  Fly   807 YRNKCV----------LIAQRI------------ARGFLARKQ----------------HRPRYQ 833
            |..|.:          |:..|.            .:|...|:|                |....:
Yeast   762 YGTKLLAGKKERRSMSLLGYRAFMGDYLSCNESKTKGSYIRRQVGIKDKVVFSIKGECLHSKFGR 826

  Fly   834 GIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDDAIKKIKMNPRITQREMDSMYTVV 898
            ...::.|:...|.||..|   :...||:........|: ||  :.||| ...:|..:.|.| .|:
Yeast   827 SAQRLKKVFILTKKTFYI---IGQTREQNAMKYTQDYK-ID--VGKIK-QVSLTNLQDDWM-GVI 883

  Fly   899 MANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAEMETRR 963
            :.|..:....:||..|    .|...||:|:.|.:.. :.....|..:|..::...|.|..
Yeast   884 LVNSTQSDPLINTPFK----TELMTRLKKLNEKIMI-KVGPTIEYHKQPNKLHTVRSKIS----- 938

  Fly   964 KAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHELALRLANESNGQVEDSPP 1028
                                     :...|....|:......||.|.     ||..:.:...:|
Yeast   939 -------------------------DSAPKYGDIYKSSTIYVRRGHP-----ANSKSNKKPKNP- 972

  Fly  1029 VIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQK 1077
                |.....|:...|    |:..|.....:.::|....|::|.|..||
Yeast   973 ----GGLSGKPIKSKK----SKHKSTHKHTHSHRSHRDAAKKQPLPSQK 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	247/710 (35%)
		CBD_MYO6-like	765..913	CDD:409646	38/194 (20%)
		ERM_helical	<954..1020	CDD:466641	9/65 (14%)
		MYO6_MIU_linker	1002..1093	CDD:480843	17/76 (22%)
		MyUb_Myo6	1076..1116	CDD:439319	2/2 (100%)
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	316/1089 (29%)