DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and MYO4

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_009373.1	Gene:	MYO4 / 851204	SGDID:	S000000027	Length:	1471	Species:	Saccharomyces cerevisiae

Alignment Length:	1102	Identity:	316/1102 - (28%)
Similarity:	526/1102 - (47%)	Gaps:	208/1102 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WVRDAAEGYIQGRITE----IGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDH---------- 59
            |.....:|:|.|.:|:    .|....|:...|.:    |...:.  :|.:...||
Yeast    10 WYPHKEQGWIGGEVTKNDFFEGTFHLELKLEDGE----TVSIET--NSFENDDDHPTLPVLRNPP 68

  Fly    60 -----DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRS 119
                 ||...|..|||...|..:|.||...:||||...:|||.||:.::..||:.:.|:.|:.:.
Yeast    69 ILESTDDLTTLSYLNEPAVLHAIKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKR 133

  Fly   120 LGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDS--------AG 176
            ..||.||:||||::|.|.|...|.:|:::||||||||||.|.||:::|.....:|        ..
Yeast   134 KDELEPHLFAIAEEAYRFMVHEKANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMS 198

  Fly   177 PIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAE 241
            .||::||..||::|||||||||||:|||||||::::.:|....:.|..|..|||||||:..|...
Yeast   199 QIESQILATNPIMEAFGNAKTTRNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPET 263

  Fly   242 ERNYHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLK 306
            |||||:||.:|.|.|:.::.:|.|..|.||.|        .|...:..|.|
Yeast   264 ERNYHIFYQILEGLPEPVKQELHLSSPKDYHY--------TNQGGQPNIAG-------------- 306

  Fly   307 DPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQS 371
               ||:.:.:.....||..:|::...:|||:.::|.:||:|||..:...:|..     ..:.||:
Yeast   307 ---IDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIGNIEMKMTRNDAS-----LSSEEQN 363

  Fly   372 LTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIV 436
            |.|...|||:|.......:|.:.:.:     :...|:..|...:|..|||::||.|||.|||.:|
Yeast   364 LQIACELLGIDPFNFAKWIVKKQIVT-----RSEKIVTNLNYNQALIARDSVAKFIYSTLFDWLV 423

  Fly   437 GLINQS-----IPFQASNF-YIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495
            ..||::     :..|...| :||:|||.|||:|..||||||||||.|||||:.||.::.|.|||.
Yeast   424 DNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLEQEE 488

  Fly   496 YKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSW---ANHYRL 557
            |.:|.:....|.|:|||..|:|||.|. ||.:||||||:||..|...:.::::.::   .::...
Yeast   489 YVKEEIEWSFIEFSDNQPCIDLIENKL-GILSLLDEESRLPSGSDESWASKLYSAFNKPPSNEVF 552

  Fly   558 GLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF- 621
            ..||..:.|          |:|.|:|..|.|..|.|||||.|::......:.:...||:.:.:.
Yeast   553 SKPRFGQTK----------FIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATTNPIFKQILD 607

  Fly   622 ---------PSGSSTS------VRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMI 671
                     |...:|.      .|......::||.||..|||||..:.....::||||||||:..
Yeast   608 NRELRSDDAPEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMAIINSTNVHYIRCIKPNSEKK 672

  Fly   672 DRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADL---------YSMYKSVL-PPELVSLPA 726
            ..:|:..:.|:||:..|.:..:.:...|:|||..|.:.         ||::..:| .|:|.....
Yeast   673 PWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILYNPDLPKEAI 737

  Fly   727 RTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDPENMLAIV--------------- 776
            ..||:::..:....:..::.|.||:||:.|.....:: :|::..|.:.|:
Yeast   738 VNFCQSILDATISDSAKYQIGNTKIFFKAGMLAFLEK-LRTNKMNEICIIIQKKIRARYYRLQYL 801

  Fly   777 ----------AKVKKWLIRSR------------------------WVKSALGALCVIKL----RN 803
                      ::::..|:|:|                        :.::|:|.  :|||    :.
Yeast   802 QTMESIKKCQSQIRSLLVRTRVDHELKTRAAILLQTNIRALWKREYYRAAIGQ--IIKLQCTCKR 864

  Fly   804 RII---YRNKCVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTL------------------K 847
            ::|   ...|.:|:|..|.:.::....|:..|:.:.:.:.:..:.:                  :
Yeast   865 KLILDSVNRKFMLMAAVIIQSYIRSYGHKTDYRTLKRSSILVQSAMRMQLARRRYIVLQKEVEER 929

  Fly   848 TIEIASGLKMGREEI---------ISGVNDIYRQIDDAIKKIKMN-PRITQREMDSM---YTVVM 899
            .|..:.|:.:..|.|         :..:||.|.::...::....| |...::|.:::   |...:
Yeast   930 NIRASYGIGLLEEAIEFKNSFILNLEMLNDSYTRLTQLLQGDLSNIPSKQRQEYETIVNGYNDKI 994

  Fly   900 ANMNKLTVDLNTKLKEQQQAEEQERLRK--IQEALEAERAAKEAEEQRQREEIENKRLKAEM 959
            :.:..|.|::...|.::...:|:::.:.  ||..:::..|.|..:..|..:|:  |.:|.|:
Yeast   995 SKLKTLQVEIMNTLNKKNALKERKKKQSSLIQSHMQSLAAIKGNKPSRLSDEV--KSMKQEL 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832	9/39 (23%)
		Myosin_head	59..754	CDD:278492	261/752 (35%)
		MYSc_Myo6	71..754	CDD:276833	254/725 (35%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	316/1102 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1622
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860