Protein Alignment jar and myo1hb

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_073808376.1
• Gene: myo1hb / 796782
• ZFINID: ZDB-GENE-070705-355
• Length: 1090
• Species: Danio rerio
• Alignment Length: 1164
• Identity: 335/1164 - (28%)
• Similarity: 522/1164 - (44%)
• Gaps: 228/1164 - (19%)

  Fly    37 RKYP--------KRTCHFDDIHSSCDGPQDHDDNCELML------------------------LN 69
            :|||        |..|...:: |.|.. :..::.|:.:|                        .:
Zfish    28 KKYPILYQESAVKHVCGAAEL-SDCIN-KSLEERCQRILQEMEGSLTARDRVGIQDFVLLDAYTS 90

  Fly    70 EATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKA 134
            |..|:||||.|:.::.||||:..:|::||||:|: .:|....:..|.|.:..|||||:||:||..
Zfish    91 ETAFMDNLKKRFNENLIYTYIGTLLVSVNPYKEL-GIYTKKQMDIYMGVNFFELPPHIFALADNV 154

  Fly   135 IRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKILD--------ANPVLEA 191
            .|.|.....:..|::||||||||||::|.:|::...|..|     |::||        :||||||
Zfish   155 YRTMISETSNHFILISGESGAGKTEASKKVLQFYAVSCPS-----TRLLDNVRDRLLLSNPVLEA 214

  Fly   192 FGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAP 256
            ||||||.:|:|||||||::::.:|.:...|||:|..|||||||:..|:..|||:|:||.|:.|..
Zfish   215 FGNAKTLKNDNSSRFGKYMDIQFDHQGAAVGGHILSYLLEKSRVVHQNHGERNFHIFYQLVEGGE 279

  Fly   257 QQLRDKLSLGKP-DDYRYL--SGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHFHN 318
            .:|...|.|.:. ..||||  ..|      ||...                     |:|...:..
Zfish   280 DELLRWLGLERNCQSYRYLIQGEC------AKVSS---------------------INDKSDWKT 317

  Fly   319 LDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQ 383
            :.|||..:..|:.:...:::::|:||||||:.||.   ..:|..:::.:.|  :...|.|||:..
Zfish   318 VQKALTIIEFSEKDIEHLFAIIASVLHLGNVHFEA---TFQGYARLNSSGE--IHWLSKLLGIPS 377

  Fly   384 TELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPFQAS 448
            ..|:..|..|.:::     |...::.|.....|..||||||||||.|.|..:|..||:|:..:.|
Zfish   378 DMLQEGLTHRKIEA-----KAEEVLSPFTAEHAKYARDALAKAIYGRTFSWLVNKINESLANKDS 437

  Fly   449 --NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDN 511
              ...||:|||.|||.|.||||||||||:||||||:.|....||:|||.|:.||:....:.:.:|
Zfish   438 TRKTVIGLLDIYGFEVFDVNSFEQFCINFCNEKLQQLFIQLTLKSEQEEYEMEGIEWEPVPYFNN 502

  Fly   512 QDIIELIEAKSNGIFTLLDEESKLPKPSYSH-FTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEE 575
            :.|.:|:|.|..||.::||||...|..:... |..::....:.|......:.:..|..:||  |.
Zfish   503 KIICDLVEEKHRGIISVLDEECLRPGEATDFTFLEKLEGKMSGHPHFVTHKLADQKTRKTL--ER 565

  Fly   576 G-FLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVG 639
            | |.:.|:||.|.|:...|::||||.|:.:::.::::..|.::|..|   .:....||....:|.
Zfish   566 GDFRLLHYAGEVTYSVVGFLDKNNDLLYRNIKEVMRQSKNSIIQHCF---HTIEPDGKKRPETVA 627

  Fly   640 SKFKTQLGELMEKLEQNGTNFIRCIKPN-SKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSR 703
            ::||..|..|.|.|......::||:||| .|..|| |:..:...|:|..|.:..|.:...|:..|
Zfish   628 TQFKNSLAGLTEILMTKEPWYVRCLKPNHCKQPDR-FDDVMVRHQVKYLGLMEHLRVRRAGFAYR 691

  Fly   704 VLFADLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGK--FVEFDR 763
            ..:......||::.|   |.....||.. .:.:.:.|.....::|.|.||:|.|..:  |...|.
Zfish   692 RRYEVFLKRYKALCPDTWPHWKGTPAEG-VQRLIKHLGYKTDEYKMGRTKIFIRHPRTLFATEDA 755

  Fly   764 IMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQH 828
            ......|....|.||.|.:.::..:::....|..:                 :...||..||::.
Zfish   756 FEVCKHELATRIQAKYKGYRVKGDYLRQREAATKI-----------------ETCWRGLQARRER 803

  Fly   829 RPRYQGIGKINKIRTNTLKTIEIASGLK--MGREEIISGVNDIY----RQIDDAIKKIKMNPRIT 887
            ..|...:..|.|.             :|  |.|.:.:|..|..|    ||
Zfish   804 ERRAWAVKVIKKF-------------IKGFMNRNQPVSMDNSEYLAFVRQ--------------- 840

  Fly   888 QREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQE-RLRKIQEALEAERAAKEAEEQRQREEIE 951
                 |..|.:..|:.|..:|..|.|......:|.. .||.:...|...:..:....|| :.:::
Zfish   841 -----SYLTRLKENLPKSVLDKTTWLTPPPIMQEASVLLRNLYTRLLVRKYVRGISAQR-KMQLQ 899

  Fly   952 NKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQ------LEKEAKDDAKYRQQLEQERRDHE 1010
            .|.|.:|:...||.:..|.:.|...|.|    :.||      |:....:..||
Zfish   900 TKALTSEIFRGRKESYPQSVCQPFADTR----ISEQDINIKVLQLICPEGIKY------------ 948

  Fly  1011 LALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGK 1075
                           |.|||:...|...|       .|.|::...|:.||        .::|..|
Zfish   949 ---------------SVPVIKYDRNGFRP-------RFRQLIFTQAAAYL--------VEEAKIK 983

  Fly  1076 QKYDLSKWK---YSELRD---AINTSCDI-----ELLEACRQEFHRRLKVYHAWKAKNR 1123
            |:.:.|..|   .|.|.|   .::.:|:.     :|:..|...|....|:  ....|||
Zfish   984 QRVNYSSLKGVSVSNLSDNFLILHVACEDTKQKGDLVLQCSYLFEALTKI--CVVTKNR 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	5/19 (26%)
		MYSc_Myo6	71..754	CDD:276833	247/701 (35%)
		CBD_MYO6-like	765..913	CDD:409646	27/153 (18%)
		ERM_helical	<954..1020	CDD:466641	13/71 (18%)
		MYO6_MIU_linker	1002..1093	CDD:480843	19/96 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	11/50 (22%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo1hb	XP_073808376.1	None