Protein Alignment jar and Myh10

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_006534552.1
• Gene: Myh10 / 77579
• MGIID: 1930780
• Length: 2007
• Species: Mus musculus
• Alignment Length: 1461
• Identity: 392/1461 - (26%)
• Similarity: 635/1461 - (43%)
• Gaps: 346/1461 - (23%)

  Fly     6 QLVWVRDAAEGYIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQ--DHDDNCELMLL 68
            :|||:.....|:....|.|....|..|...:.. .|...:.||| ...:.|:  ..:|..||..|
Mouse    34 KLVWIPSERHGFEAASIKEERGDEVMVELAENG-KKAMVNKDDI-QKMNPPKFSKVEDMAELTCL 96

  Fly    69 NEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADK 133
            |||:.|.|||.|||...||||.....:.:|||:.: .:|:.:.|:.|.|:...|:|||::||::.
Mouse    97 NEASVLHNLKDRYYSGLIYTYSGLFCVVINPYKNL-PIYSENIIEMYRGKKRHEMPPHIYAISES 160

  Fly   134 AIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCY---SHDS----------------AGPIE 179
            |.|.|...:..|||:.:|||||||||:||.:::||.:   ||..                .|.:|
Mouse   161 AYRCMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKGRKDHNIPQESPKPVKPQGELE 225

  Fly   180 TKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERN 244
            .::|.|||:||:||||||.:|:|||||||||.:::|....:||..|..|||||||...|:.:||.
Mouse   226 RQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAVRQAKDERT 290

  Fly   245 YHVFYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPI 309
            :|:||.||:||.:.|:..|.|...::||:||  ..|..       |||.|
Mouse   291 FHIFYQLLSGAGEHLKSDLLLEGFNNYRFLS--NGYIP-------IPGQQ--------------- 331

  Fly   310 IDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTI 374
              |..:|....:|:..:|.|..|.|.:..:|::||..|||:|::..:       ..:||....|:
Mouse   332 --DKDNFQETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERN-------TDQASMPENTV 387

  Fly   375 TS---GLLGVDQTEL-RTALVSRV---------MQSKGGGFKGTVIMVPLKIYEASNARDALAKA 426
            ..   .|||::..|. |..|..|:         .|:|               .:|..|.:|||||
Mouse   388 AQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTK---------------EQADFAVEALAKA 437

  Fly   427 IYSRLFDRIVGLINQSI---PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNI 488
            .|.|||..:|..||:::   ..|.::| ||:|||||||.|.:|||||.||||.|||||:.||..:
Mouse   438 TYERLFRWLVHRINKALDRTKRQGASF-IGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTM 501

  Fly   489 LKNEQELYKREGLNVPEITF-TDNQDIIELIEAKSN--GIFTLLDEESKLPKPSYSHFTAEVHKS 550
            ...|||.|:|||:....|.| .|.|..|:|||..:|  |:..|||||...||.:...|..::.:.
Mouse   502 FILEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVEKLVQE 566

  Fly   551 WANHYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNND--------ALHASLEG 607
            ..:|        |:.:..|.|:|:..|.:.|:||.|.|..::::.||.|        .||.|.:.
Mouse   567 QGSH--------SKFQKPRQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDR 623

  Fly   608 LVQECDNPLLQTLFPSGSSTSVRG------------------------------KLNFISVGSKF 642
            .|.|.....:||:..:....||.|                              |..|.:||..:
Mouse   624 FVAELWKDEIQTIQRASFYDSVSGLHEPPVDRIVGLDQVTGMTETAFGSAYKTKKGMFRTVGQLY 688

  Fly   643 KTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFA 707
            |..|.:||..|.....||:|||.||.:....:.:..|.|.||:|:|.:..:.:...|:|:|::|.
Mouse   689 KESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQ 753

  Fly   708 DLYSMYKSVLPPELVS---LPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDP 769
            :....|: :|.|..:.   :..:..||.|.::|.|....::.|.:|:|||.|
Mouse   754 EFRQRYE-ILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRAG------------- 804

  Fly   770 ENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQG 834
              :||.:.:.:.                 :|:.:.||:       .|.:.||:||||....:.|.
Mouse   805 --VLAHLEEERD-----------------LKITDIIIF-------FQAVCRGYLARKAFAKKQQQ 843

  Fly   835 IGKINKIRTNTLKTIEIASG------------LKMGREEIISGVNDIYRQIDDAIKKIKMNPRIT 887
            :..:..::.|....:::...            |::.|:|      :..:..|:.:.|:|......
Mouse   844 LSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQE------EELQAKDEELLKVKEKQTKV 902

  Fly   888 QREMDSM--------------------YTVVMANMNKLTVDLNTKLKEQQQ---------AEEQE 923
            :.|::.|                    .|.:.|...::...|..|.:|.::         .||:|
Mouse   903 EGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEE 967

  Fly   924 R--------------LRKIQEALEAERAAK----------EAEEQRQREEI-----ENKRL---K 956
            |              ::.::|.|:.|..|:          ||:.::..||:     :|.:.   |
Mouse   968 RNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEVLLLEDQNSKFIKEK 1032

  Fly   957 AEMETRRKAAEAQRLRQEEEDRRAALALQEQ------LEKEAKDDAKYRQQLEQERRD------- 1008
            ..||.|.....:|...:||:.:..|....:|      ||:..|.:.|.||:||:.:|.
Mouse  1033 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTD 1097

  Fly  1009 ------------HELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLN 1061
                        .||.::|..:.    |:....:..|  |...:..|..:..::.:....:....
Mouse  1098 LQDQIAELQAQVDELKVQLTKKE----EELQGALARG--DDETLHKNNALKVARELQAQIAELQE 1156

  Fly  1062 KSENVRAQQQALGKQKYDLS---KWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNR 1123
            ..|:.:|.:....|||.|||   :...:||.|.::|:       |.:||    |:.....:....
Mouse  1157 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT-------AAQQE----LRTKREQEVAEL 1210

  Fly  1124 KRTTMDENERAPRSVMEAAFKQPPLVQPIQEIVTAQHRYFRIPFMRANAPDNTKRGLWYAHFDGQ 1188
            |:...||.:.....:.:...:....::.:.|.:....|:      :||...| |:||   ..|.:
Mouse  1211 KKALEDETKNHEAQIQDMRQRHATALEELSEQLEQAKRF------KANLEKN-KQGL---ETDNK 1265

  Fly  1189 WIA------RQMELHADKPPILLVAGTDDMQMCELSLEETGLTRKR-----GAEILEHEFN---- 1238
            .:|      :|::..::.....|     |.|:.||..:.:...|.|     .|..|::|.:
Mouse  1266 ELACEVKVLQQVKAESEHKRKKL-----DAQVQELHAKVSEGDRLRVELAEKANKLQNELDNVST 1325

  Fly  1239 --REWERNGGKAYKNLGAAKPNGPAAAMQKQ 1267
              .|.|:.|.|..|:         ||.::.|
Mouse  1326 LLEEAEKKGIKFAKD---------AAGLESQ 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	10/41 (24%)
		MYSc_Myo6	71..754	CDD:276833	257/761 (34%)
		CBD_MYO6-like	765..913	CDD:409646	25/179 (14%)
		ERM_helical	<954..1020	CDD:466641	21/93 (23%)
		MYO6_MIU_linker	1002..1093	CDD:480843	21/112 (19%)
		MyUb_Myo6	1076..1116	CDD:439319	13/42 (31%)
		Myosin-VI_CBD	1160..1246	CDD:465157	22/102 (22%)
Myh10	XP_006534552.1	Myosin_N	31..76	CDD:460670	10/42 (24%)
		MYSc_Myh10	99..802	CDD:276952	257/761 (34%)
		Myosin_tail_1	879..1959	CDD:460256	98/516 (19%)