Protein Alignment jar and Myo3a

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_680779.4
• Gene: Myo3a / 667663
• MGIID: 2183924
• Length: 1613
• Species: Mus musculus
• Alignment Length: 1264
• Identity: 337/1264 - (26%)
• Similarity: 545/1264 - (43%)
• Gaps: 291/1264 - (23%)

  Fly    22 ITEIGAKEFEVTPT----------------DRKYPKRTCHFDDIHSSCDGP-------------- 56
            |::...|::|..||                |....|:...|.||| .|.|.
Mouse   264 ISKCLTKDYEKRPTVSDLLKHKFITQIEGKDVILQKQLMEFIDIH-QCLGSTEKARHERIHTKKG 327

  Fly    57 ----------QDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDT 111
                      :|.||...|.:|:|.|..::|:..|.:|:||.||.:||||:||::.: .:|:...
Mouse   328 NLNRSLISSLKDVDDLATLDVLDENTVSEHLEKCYSRDQIYIYVGDILIALNPFQSL-GIYSTKL 391

  Fly   112 IKKYNGRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYL-CYSHDSA 175
            .:.|.|......|||:||:||...:.|..|...|.|::|||||||||||...|::.| .....:.
Mouse   392 SRLYIGAKRTANPPHIFAMADLGYQSMVTYNADQCIVISGESGAGKTESAHLLVQQLTVLGKANN 456

  Fly   176 GPIETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSA 240
            ..::.|||..|.::||||||.|..|:|||||||::|:.:.:...|||..||.|||||||:..|:.
Mouse   457 RTLQEKILQMNNLVEAFGNACTIINDNSSRFGKYLEMKFTSSGAVVGAQISEYLLEKSRVIHQAI 521

  Fly   241 EERNYHVFYMLLAGAPQQLRDKLSLGK-PDDY--RYLSGCTQYFANAKTEQLIPGSQKSKNHQQK 302
            .|:|:|:||.:.||..:  :.||:|.| |::.  |||..     .|.:|.|.:..:...|:
Mouse   522 GEKNFHIFYYIYAGLAE--KKKLALYKLPENKPPRYLQN-----DNLRTVQDMMNNSFYKS---- 575

  Fly   303 GPLKDPIIDDYQHFHNLDKALGRLGLSDTEKLG-IYSLVAAVLHLGNIAFEEIPDDVRGGCQVSE 366
                     .|:......|.:|    ...|:|| :||::||:|::|||.|..:..:.    |:.:
Mouse   576 ---------QYELIEQCFKVIG----FTMEQLGSVYSVLAAILNVGNIEFSSVATEY----QMDK 623

  Fly   367 A---SEQSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIY 428
            :   :..:|..::.||.:...||:.||.|..:.:     :|..|:.|..:.:|::.|||:||.:|
Mouse   624 SYICNHTALENSASLLCIQADELQEALTSHCVVT-----RGETIIRPNTVEKAADVRDAMAKTLY 683

  Fly   429 SRLFDRIVGLINQSIPFQAS-----NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNI 488
            .|||..||..||..:....|     ...||:|||.|||.|..|||||.|||..||::|.:||.::
Mouse   684 GRLFSWIVNCINSLLKHDTSPSGDEELNIGILDIFGFENFKRNSFEQLCINIANEQIQYYFNQHV 748

  Fly   489 LKNEQELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWAN 553
            ...||..|..|.::...|.:.||:.::::...|..|:.:||||||:.||.:......:...:..:
Mouse   749 FAWEQNEYLNEDVDARVIEYEDNRPLLDMFLQKPMGLLSLLDEESRFPKATDQTLIEKFEDNLKS 813

  Fly   554 HYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDN---- 614
            .|           ..|..|.|..|.:.|:||.|.|:...|:.||.|.....:..|::..:|
Mouse   814 QY-----------FWRPKRMELSFGIHHYAGKVLYSASGFLAKNRDTFPTDIVLLLRSSENSVIR 867

  Fly   615 -----PLLQT---------------LFPSGSSTSV-RGKLNFI-------------SVGSKFKTQ 645
                 ||.:|               ::.|..||:: :|:...:             :|.|.|:..
Mouse   868 QLVNHPLTKTGNLPLSKTKNIVNYQMWNSEKSTNLTKGETRDVTCHACETTNVKTQTVSSYFRYS 932

  Fly   646 LGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLY 710
            |.:|:.|:.....:|:||||||::...|:::....|.||:|:|.:....:...||..|:|||:..
Mouse   933 LMDLLSKMVVGQPHFVRCIKPNNERQARKYDKEKVLLQLRCTGILETARIRRLGYSHRILFANFI 997

  Fly   711 SMY------KSVLPPELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKF--VEFDRIMRS 767
            ..|      .|..||  ||...   |.|:.:...|.  ::..|.||||.   |:  ||...:||.
Mouse   998 KRYYILCYKSSEEPP--VSPDT---CAAILEKAGLD--NWALGKTKVFL---KYYHVEQLNLMRK 1052

  Fly   768 DPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRY 832
            :..|.|.::         ...|::.|||....:|:.:   |....:|.|..||..|.|| |....
Mouse  1053 EATNKLVLI---------QASVRAFLGARRYQELQQK---RKSSAVIIQSAARRHLLRK-HGKET 1104

  Fly   833 QGI----GK----------------------INKIRTNTLKTIEIASGLKMGREEIISGVNDIYR 871
            ..:    |:                      :.|...|.:.|.|..:.....:|...:|....:|
Mouse  1105 SNVKSAAGRSIRAKDQEFDYKKNFETKRESFVKKQTENAVPTNESNTSTPNNKESPSAGKTAPFR 1169

  Fly   872 QIDDAIKKIKMNPRI-TQREMDSMYTVVMANMNK-------LTVDLNTKLKEQQQAEEQERLRKI 928
            ....|......|.|. ||::|.::|.   ...|:       ...:::.:.|..|..||..::||.
Mouse  1170 AESKATNVESNNRRYHTQKKMSNVYA---EGQNQELYIVEDTWAEVSPRQKYVQDLEESRKMRKE 1231

  Fly   929 QEA-----------------LEAERAAKEAEEQRQREEIENKRLKAEMETRR-------KAAEAQ 969
            ::.                 .|::....|..|..:|.......|..|:..|:       :.:..|
Mouse  1232 EKGDAVIQSYCQWYTEGSNFEESKATCLEGRETWERTSCPGLWLTEEIYLRKTLDPTLSQKSVYQ 1296

  Fly   970 RLRQEEEDRRAALALQE-------------------------QLEKEAK--------DDAKYRQQ 1001
            ....:|::.:.::..|.                         |.::|.|        ..:|.:||
Mouse  1297 NADGKEKEHKVSVVTQNAPLGNLERDYHLLGFLGEEDTGPVPQAQEEHKAVSIHSKYQSSKKKQQ 1361

  Fly  1002 LEQERRDHELALRLANE----SNGQVEDSP------PVIRNGVNDA-------SPMGPNK----L 1045
            |.::|    ||....|:    |:.:|..:.      |..:.||:.:       |.|...|    |
Mouse  1362 LGKDR----LAPPFKNQKILSSSTEVAKTTHNVYPCPTKQEGVHHSKMVDERDSKMASKKEAWDL 1422

  Fly  1046 ISFSQVVSNIASRYL----NKSENVRAQQ 1070
            ..||:.:|.::..|.    |.:|.:.|||
Mouse  1423 AMFSRQISKLSEEYFILQKNLNEIILAQQ 1451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	8/42 (19%)
		MYSc_Myo6	71..754	CDD:276833	236/739 (32%)
		CBD_MYO6-like	765..913	CDD:409646	34/181 (19%)
		ERM_helical	<954..1020	CDD:466641	17/109 (16%)
		MYO6_MIU_linker	1002..1093	CDD:480843	23/94 (24%)
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
Myo3a	NP_680779.4	Protein Kinases, catalytic domain	2..287	CDD:473864	5/22 (23%)
		MYSc_Myo3	352..1040	CDD:276830	236/742 (32%)
		MBD_Myo3a	1407..1454	CDD:439318	13/45 (29%)