DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and Myo1c

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_038942736.1	Gene:	Myo1c / 65261	RGDID:	620443	Length:	1063	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	334/1128 - (29%)
Similarity:	537/1128 - (47%)	Gaps:	187/1128 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 AKEFEVTPTDR----KYPKRTCHF----DDIHSSCD---------GPQDHDDNCELMLL----NE 70
            |.:.|:.||..    .:|.|.|..    |.:..:.:         |.||      .:||    :|
  Rat     2 ALQVELIPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQD------FVLLENFTSE 60

  Fly    71 ATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPPHVFAIADKAI 135
            |.|::||:.|:.::.||||:..:|::|||||:: ::|....:::|.|.|..|:|||:||:||...
  Rat    61 AAFIENLRRRFRENLIYTYIGPVLVSVNPYRDL-QIYTRQHMERYRGVSFYEVPPHLFAVADTVY 124

  Fly   136 RDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPIETKILDANPVLEAFGNAKT 197
            |.:|..:..|::::||||||||||:||.||::   .|.:.:..|.:..::|.:||||||||||||
  Rat   125 RALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKT 189

  Fly   198 TRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYMLLAGAPQQLRDK 262
            .||:|||||||:::|.:|.|...|||:|..|||||||:..|:..|||:||||.||.|..::...:
  Rat   190 LRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEEALRR 254

  Fly   263 LSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGP-LKDPIIDDYQHFHNLDKALGR 325
            |.|.: |..|.||                          .||. .|...|:|...:..:.|||..
  Rat   255 LGLERNPQSYLYL--------------------------VKGQCAKVSSINDKSDWKVVRKALSV 293

  Fly   326 LGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGLLGVDQTELRTAL 390
            :..::.|...:.|:||:|||||||.|..   |.....||:  :|..|...:.||||:.|.||.||
  Rat   294 IDFTEDEVEDLLSIVASVLHLGNIHFAA---DEDSNAQVT--TENQLKYLTRLLGVEGTTLREAL 353

  Fly   391 VSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI-------PFQAS 448
            ..|.:.:     ||..::.||.:.:|:.||||||||:|||.|..:|..||:|:       |...|
  Rat   354 THRKIIA-----KGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRS 413

  Fly   449 NFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFTDNQD 513
            ...:|:|||.|||.|..||||||||||||||||:.|.:..||:|||.|:.||:....:.:.:|:.
  Rat   414 TTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKI 478

  Fly   514 IIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDEEGF 577
            |.:|:|.|..||.::||||...| :.:...|..::..:..:|......:.:..|..::| |...|
  Rat   479 ICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQKTRKSL-DRGEF 542

  Fly   578 LVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSSTSVRGKLNFISVGSKF 642
            .:.|:||.|.|:...|::||||.|..:|:..:....||::...|   ..:.:..|....:|.::|
  Rat   543 RLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCF---DKSELSDKKRPETVATQF 604

  Fly   643 KTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFA 707
            |..|.:|:|.|......:|||||||......:|:..|...|:|..|.:..|.:...|:..|..:.
  Rat   605 KMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYE 669

  Fly   708 DLYSMYKSVLP---PELVSLPARTFCEAMFQSLNLSAKDFKFGITKVFFRPGKFVEFDRIMRSDP 769
            .....|||:.|   |.....| :.....:.:.|....:::|.|.||:|.|      |.:.:.:..
  Rat   670 AFLQRYKSLCPETWPVWTGRP-QDGVAVLVRHLGYKPEEYKMGRTKIFIR------FPKTLFATE 727

  Fly   770 ENM----LAIVAKVK------KWLIRSRWVKSALGALCVIKL------RNRIIYRNKCVLIAQRI 818
            :::    .::..|::      .|  |.::::....|:|:...      |.:...|.......:|:
  Rat   728 DSLEVRRQSLATKIQAAWRGFHW--RQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRL 790

  Fly   819 ARGFLARKQHRPRY-QGIGKINKIRTNTLKTIEIASGLKMGREEIISGVND--------IYRQID 874
            .|||:.|  |.||. :....::.:||:.|..:         |.::...|.|        ..|:..
  Rat   791 IRGFILR--HAPRCPENAFFLDHVRTSFLLNL---------RRQLPRNVLDTSWPTPPPALREAS 844

  Fly   875 DAIKKIKMNPRITQREMDSMYTVVMANMN-KLTVDLNTKLKEQQQAEEQERLRKIQEALEAE--R 936
            :.::::                 .|.||. |....::.:.|:|.|          |:|:.:|  :
  Rat   845 ELLREL-----------------CMKNMVWKYCRSISPEWKQQLQ----------QKAVASEIFK 882

  Fly   937 AAKEAEEQRQREEIENKRLKAEMETRRKAAEAQRLRQE---------EEDRRAALALQEQLEKEA 992
            ..|:...|.......:.||..|..:.|   ..|.|..|         :.||:.......||....
  Rat   883 GKKDNYPQSVPRLFISTRLGTEEISPR---VLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTP 944

  Fly   993 K-----DDAKYRQQLEQERRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVV 1052
            .     :|||.:|:::.        ..|...|...:.||..|:.....|:...| :.::....|:
  Rat   945 SAVVIVEDAKVKQRIDY--------ANLTGISVSSLSDSLFVLHVQREDSKQKG-DVVLQSDHVI 1000

  Fly  1053 SNIASRYL--NKSENVRAQQQAL 1073
            ..:....|  ::..|:...|.::
  Rat  1001 ETLTKTALSADRVNNININQGSI 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832	6/21 (29%)
		Myosin_head	59..754	CDD:278492	261/714 (37%)
		MYSc_Myo6	71..754	CDD:276833	258/698 (37%)
		RILP-like	<968..1015	CDD:304877	11/60 (18%)
		Myosin-VI_CBD	1160..1246	CDD:293129
Myo1c	XP_038942736.1	MYSc_Myo1	62..718	CDD:276829	257/697 (37%)
		IQ	756..776	CDD:197470	3/19 (16%)
		Myosin_TH1	874..1055	CDD:399188	30/162 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920