DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jar and MYO1G

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_149043.2	Gene:	MYO1G / 64005	HGNCID:	13880	Length:	1018	Species:	Homo sapiens

Alignment Length:	799	Identity:	260/799 - (32%)
Similarity:	403/799 - (50%)	Gaps:	82/799 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            :.:||::.|   |:.||:.|:.|.:||||:..:|::||||:|: .||.|:.|.:|.||.|.|.||
Human    13 DFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQEL-PLYGPEAIARYQGRELYERPP 76

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDA 185
            |::|:|:.|.:.|:.......|::||||||||||::|::::|:....:.:...|.:     :|.:
Human    77 HLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKS 141

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ..||||||||:|.||:|||||||::::::|.|...:||:|..|||||||:..|...|||:|.||.
Human   142 TCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQ 206

  Fly   251 LLAGAPQQLRDKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKG---PLKDPIID 311
            ||.|:..:...:|.|.: |..|.:                        .||..|   .:...:..
Human   207 LLRGSEDKQLHELHLERNPAVYNF------------------------THQGAGLNMTVHSALDS 247

  Fly   312 DYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQ---VSEASEQSLT 373
            |.|....:.:|:..:|.|..|...::.::||:||||||.|.|..:   ||.|   ::.|.|..:.
Human   248 DEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEE---GGLQKEGLAVAEEALVD 309

  Fly   374 ITSGLLGVDQTELRTALVSRVMQSKGGGF--KGTVIMVPLKIYEASNARDALAKAIYSRLFDRIV 436
            ..:.|....:..:..:|::|.:.|.|...  ||....      |||.||||.|||:|.|||:.:|
Human   310 HVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAA------EASYARDACAKAVYQRLFEWVV 368

  Fly   437 GLINQSIP-------FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQE 494
            ..||..:.       ....:..||||||.|||.|.|||||||||||||||||:.|...|||.|||
Human   369 NRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQE 433

  Fly   495 LYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVH-KSWANHYRLG 558
            .|:|||:....:.:.:|..|::|:|....||..:|||...    |....|..:. ::...|:|..
Human   434 EYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACS----SAGTITDRIFLQTLDMHHRHH 494

  Fly   559 LPRSSR--LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF 621
            |..:||  ....:|:.....|.::|:||.|.|:.|.||:||.|.|....:.|:....:|.|:.::
Human   495 LHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMW 559

  Fly   622 PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKC 686
            |.|...........::.|:.||..:..|:|.|......::||||||...:..:.:.:....|:..
Human   560 PDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAY 624

  Fly   687 SGTISVLELMEHGYPSRVLFADLYSMYKSVL----PPELVSLPARTFCEAMFQSLNLSAKDFKFG 747
            .|.:..:.:...|:.||..::.....||...    |..|:. ..:....|:.:...|.. |..||
Human   625 LGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLG-SDKAAVSALLEQHGLQG-DVAFG 687

  Fly   748 ITKVFFR-PGKFVEFDRIMRSDPENMLAIVAKV--KKWL-IRSRWVKSALGALCVIKLRNRIIYR 808
            .:|:|.| |...|..::    ....::.|:..:  |.|. ..:||....|.|:..|.   |...|
Human   688 HSKLFIRSPRTLVTLEQ----SRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIM---RWFRR 745

  Fly   809 NKCVLIAQRIARGFLARKQ 827
            :|.......:.|.|.|.:|
Human   746 HKVRAHLAELQRRFQAARQ 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	242/720 (34%)
		MYSc_Myo6	71..754	CDD:276833	240/713 (34%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
MYO1G	NP_149043.2	MYSc	4..706	CDD:214580	245/736 (33%)
		MYSc_Myo1	23..694	CDD:276829	239/710 (34%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	584..606		8/21 (38%)
		Myosin_TH1	815..980	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920