Protein Alignment jar and MYO1G

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: NP_149043.2
• Gene: MYO1G / 64005
• HGNCID: 13880
• Length: 1018
• Species: Homo sapiens
• Alignment Length: 799
• Identity: 260/799 - (32%)
• Similarity: 403/799 - (50%)
• Gaps: 82/799 - (10%)

  Fly    64 ELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            :.:||::.|   |:.||:.|:.|.:||||:..:|::||||:|: .||.|:.|.:|.||.|.|.||
Human    13 DFVLLDQVTMEDFMRNLQLRFEKGRIYTYIGEVLVSVNPYQEL-PLYGPEAIARYQGRELYERPP 76

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDA 185
            |::|:|:.|.:.|:.......|::||||||||||::|::::|:....:.:...|.:     :|.:
Human    77 HLYAVANAAYKAMKHRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKDVLLKS 141

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            ..||||||||:|.||:|||||||::::::|.|...:||:|..|||||||:..|...|||:|.||.
Human   142 TCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPIGGHIHSYLLEKSRVLKQHVGERNFHAFYQ 206

  Fly   251 LLAGAPQQLRDKLSLGK-PDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKG---PLKDPIID 311
            ||.|:..:...:|.|.: |..|.:                        .||..|   .:...:..
Human   207 LLRGSEDKQLHELHLERNPAVYNF------------------------THQGAGLNMTVHSALDS 247

  Fly   312 DYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQ---VSEASEQSLT 373
            |.|....:.:|:..:|.|..|...::.::||:||||||.|.|..:   ||.|   ::.|.|..:.
Human   248 DEQSHQAVTEAMRVIGFSPEEVESVHRILAAILHLGNIEFVETEE---GGLQKEGLAVAEEALVD 309

  Fly   374 ITSGLLGVDQTELRTALVSRVMQSKGGGF--KGTVIMVPLKIYEASNARDALAKAIYSRLFDRIV 436
            ..:.|....:..:..:|::|.:.|.|...  ||....      |||.||||.|||:|.|||:.:|
Human   310 HVAELTATPRDLVLRSLLARTVASGGRELIEKGHTAA------EASYARDACAKAVYQRLFEWVV 368

  Fly   437 GLINQSIP-------FQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQE 494
            ..||..:.       ....:..||||||.|||.|.|||||||||||||||||:.|...|||.|||
Human   369 NRINSVMEPRGRDPRRDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQE 433

  Fly   495 LYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVH-KSWANHYRLG 558
            .|:|||:....:.:.:|..|::|:|....||..:|||...    |....|..:. ::...|:|..
Human   434 EYEREGITWQSVEYFNNATIVDLVERPHRGILAVLDEACS----SAGTITDRIFLQTLDMHHRHH 494

  Fly   559 LPRSSR--LKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF 621
            |..:||  ....:|:.....|.::|:||.|.|:.|.||:||.|.|....:.|:....:|.|:.::
Human   495 LHYTSRQLCPTDKTMEFGRDFRIKHYAGDVTYSVEGFIDKNRDFLFQDFKRLLYNSTDPTLRAMW 559

  Fly   622 PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKC 686
            |.|...........::.|:.||..:..|:|.|......::||||||...:..:.:.:....|:..
Human   560 PDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGKLDENHCRHQVAY 624

  Fly   687 SGTISVLELMEHGYPSRVLFADLYSMYKSVL----PPELVSLPARTFCEAMFQSLNLSAKDFKFG 747
            .|.:..:.:...|:.||..::.....||...    |..|:. ..:....|:.:...|.. |..||
Human   625 LGLLENVRVRRAGFASRQPYSRFLLRYKMTCEYTWPNHLLG-SDKAAVSALLEQHGLQG-DVAFG 687

  Fly   748 ITKVFFR-PGKFVEFDRIMRSDPENMLAIVAKV--KKWL-IRSRWVKSALGALCVIKLRNRIIYR 808
            .:|:|.| |...|..::    ....::.|:..:  |.|. ..:||....|.|:..|.   |...|
Human   688 HSKLFIRSPRTLVTLEQ----SRARLIPIIVLLLQKAWRGTLARWRCRRLRAIYTIM---RWFRR 745

  Fly   809 NKCVLIAQRIARGFLARKQ 827
            :|.......:.|.|.|.:|
Human   746 HKVRAHLAELQRRFQAARQ 764

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670
		MYSc_Myo6	71..754	CDD:276833	240/713 (34%)
		CBD_MYO6-like	765..913	CDD:409646	15/66 (23%)
		ERM_helical	<954..1020	CDD:466641
		MYO6_MIU_linker	1002..1093	CDD:480843
		MyUb_Myo6	1076..1116	CDD:439319
		Myosin-VI_CBD	1160..1246	CDD:465157
MYO1G	NP_149043.2	MYSc_Myo1	23..694	CDD:276829	239/710 (34%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	584..606		8/21 (38%)
		Myosin_TH1	815..980	CDD:461801