DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1g

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_005170126.1	Gene:	myo1g / 571487	ZFINID:	ZDB-GENE-060503-562	Length:	1010	Species:	Danio rerio

Alignment Length:	1065	Identity:	324/1065 - (30%)
Similarity:	476/1065 - (44%)	Gaps:	212/1065 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ELMLLNEAT---FLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGELPP 125
            :.:||:|.|   |::|||.|:.|.:|||::..::::|||||.: ::|..|.|:.|.||.|.|.||
Zfish    13 DFVLLDEVTMEQFMENLKLRFEKSRIYTFIGEVVVSVNPYRHL-DIYGKDVIEDYRGRELYENPP 76

  Fly   126 HVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETK-----ILDA 185
            |::|:||.|.:.|:.......|::||||||||||::||:::|:....:.:...|.:     :|.:
Zfish    77 HLYAVADAAYKAMKRRAKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVESVKNVLLKS 141

  Fly   186 NPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYM 250
            |.||||||||||.||:|||||||:::::::......||:|::|||||||:..|...|||:|.||.
Zfish   142 NCVLEAFGNAKTNRNDNSSRFGKYMDINFNFNGDPTGGHINNYLLEKSRVVQQQEGERNFHSFYQ 206

  Fly   251 LLAGAPQQLRDKLSLGK-PDDYRYLS-GCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            ||.|....|...|.|.: |.:|.|.| |.:...|             |.|             |.
Zfish   207 LLRGGSDDLLKSLYLQRDPAEYTYTSQGASVTLA-------------SNN-------------DS 245

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGL 378
            |....:..||..:|.:..|...||..::.:|||||:.|      ...|..|....|..|...|.|
Zfish   246 QCHKAVMAALKVIGFTAEEISSIYKTLSTILHLGNLQF------TSDGEHVVLVGEDMLKNISEL 304

  Fly   379 LGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI 443
            ...:....|.||:.|.:.:.|    |.||.......|||..|||.|||:|.|||..|||.||..|
Zfish   305 TSTEPENTRKALLYRTVATGG----GEVIEKGHSEQEASYGRDAFAKALYERLFAWIVGRINGVI 365

  Fly   444 -------PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGL 501
                   .....|..||||||.|||.|..||||||||||||||||:.|.:.||:.|||.|:|||:
Zfish   366 EVKDYNPALHGKNTVIGVLDIYGFEIFDNNSFEQFCINYCNEKLQQLFIELILRQEQEEYQREGI 430

  Fly   502 NVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLP-KPSYSHFTAEVHKSWANHYRLGLPRSSRL 565
            ....|.:.:||.|::|:|....||.::|||...:. |.:.:.....::|....|     |..:..
Zfish   431 TWQHIEYFNNQIIVDLVEQPHKGIISVLDEACLIAGKVTDTVCLDSMNKKLGQH-----PHYTSR 490

  Fly   566 K---AHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPSGSST 627
            |   |.:|:.....|.:||:||.|.|:.:.|::||.|.|....:.|:....:|:|:.::|.|..:
Zfish   491 KLCPADKTMEFNRDFRIRHYAGDVTYSVDGFLDKNKDPLFQDFKRLMYNSSDPVLKEMWPDGKMS 555

  Fly   628 SVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISV 692
            ........::..:.||..:..|::||......::||||||      :.:..|.....:|...::.
Zfish   556 ITEVTKRPLTAATLFKNSIIALVDKLACKEPYYVRCIKPN------EVKSPLLFDDGRCQHQVAY 614

  Fly   693 LELMEH------GYPSRVLFADLYSMYKSVL----PPELVSLPARTFCEAMFQSLNLSA--KDFK 745
            |.|:|:      |:..|..:|.....||...    |..|:|    |..||:...:|...  .|..
Zfish   615 LGLLENVRVRRAGFAYRQPYARFLQRYKMTCEYTWPNHLMS----TDQEAVEAIVNQHGFEDDVA 675

  Fly   746 FGITKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGALCVIKLRNRIIYRNK 810
            :|:.|:|.|             .|..:..:              :....||..|
Zfish   676 YGLNKIFVR-------------TPRTLFTL--------------EQERAALIPI----------- 702

  Fly   811 CVLIAQRIARGFLARKQHRPRYQGIGKINKIRTNTLKTIEIASGLKMGREEIISGVNDIYRQIDD 875
            .||..|::.||.|||.:.|       ||..|.|                   |.|....|
Zfish   703 LVLFLQKVWRGALARMRCR-------KIRAIYT-------------------IMGYYKCY----- 736

  Fly   876 AIKKIKMNPRITQREMDSMYTVVMANMNKLTVDLNTKLKEQQQAEEQERLRKIQEALEAERAAKE 940
               |:|.:....:|...|:..  ||:..| :|:..|......|      ..:|.:.|.....|
Zfish   737 ---KVKAHFWEVERRFASVRN--MADYGK-SVEWPTPPAALAQ------FHRITQHLYRRWWA-- 787

  Fly   941 AEEQRQREEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQE 1005
                  |:.|:|.......|.|.|.|....|..|                  :.|..|.:..|
Zfish   788 ------RQLIKNIPPSDMAEVRAKVAAFSALSGE------------------RMDWGYSRSWE-- 826

  Fly  1006 RRDHELALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQ 1070
             ||:     |||     .:|||.:..|.|.....: .|| ..:.||:.:.|.|.||...|.:  .
Zfish   827 -RDY-----LAN-----AKDSPLMSSNFVRITKEL-KNK-DQYGQVLFSSAVRMLNWFNNTK--D 876

  Fly  1071 QAL---GKQKYDLSKWKYSELRDAI 1092
            :||   .|..|.|...|:.:::..|
Zfish   877 RALLITDKHIYRLEPKKHFKVQKRI 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	252/722 (35%)
		MYSc_Myo6	71..754	CDD:276833	249/715 (35%)
		RILP-like	<968..1015	CDD:304877	7/46 (15%)
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1g	XP_005170126.1	MYSc	8..696	CDD:214580	254/761 (33%)
		MYSc_Myo1	23..684	CDD:276829	248/712 (35%)
		Myosin_TH1	805..1002	CDD:283635	33/132 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010