DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment jar and myo1ca

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	XP_005165404.1	Gene:	myo1ca / 567536	ZFINID:	ZDB-GENE-070705-190	Length:	1045	Species:	Danio rerio

Alignment Length:	892	Identity:	287/892 - (32%)
Similarity:	448/892 - (50%)	Gaps:	135/892 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 GPQDHDDNCELMLLN---EATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYN 116
            |.||.     |:|.|   ||.|::||:.||.:..||||:.::|::||||:|: |:|:...::::.
Zfish    29 GVQDF-----LLLENHNSEAAFIENLRRRYREGLIYTYIGSVLVSVNPYKEL-EIYSKQNMERHR 87

  Fly   117 GRSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKY---LCYSHDSAGPI 178
            |.:..|:.||:||:||.:.|.:|..:..|.|::||||||||||::|.:|:|   :|.:.::...|
Zfish    88 GVNFYEISPHIFALADNSYRALRTERRDQCILISGESGAGKTEASKKILQYYTHICPTRNNTHTI 152

  Fly   179 ETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEER 243
            ..::|.:||||||||||||.||:|||||||::::.:|.|...:||:|.:|||||||:..|:..||
Zfish   153 RERLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDIQFDYKGAPIGGHILNYLLEKSRVAHQNHGER 217

  Fly   244 NYHVFYMLLAGAPQQLRDKLSLGK--PDDYRYL--SGCTQYFANAKTEQLIPGSQKSKNHQQKGP 304
            |:|:||.||.|....|..:|.|.|  |..|.||  ..|.:..:
Zfish   218 NFHIFYQLLEGGEDLLLKRLGLDKTNPQHYHYLIKGNCPRVSS---------------------- 260

  Fly   305 LKDPIIDDYQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASE 369
                 |.|...:..:..||..:|..|.|...:..:||:||||||..|.|   |..|...::  :|
Zfish   261 -----ISDKNGWKVVRNALTIIGFEDEEIQALMEIVASVLHLGNTQFGE---DEEGETHIT--TE 315

  Fly   370 QSLTITSGLLGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDR 434
            ..|...|.|||||.:.|:.||..:.:.:     ||..::.||.:.:|.:|||:.|||||.|.|..
Zfish   316 AQLQFLSQLLGVDGSVLKAALTHKKIVA-----KGEEMISPLSLEQALSARDSFAKAIYGRAFTW 375

  Fly   435 IVGLINQSIPFQASNFY-------IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNE 492
            :|..:|:|:.|:...:|       ||:|||.|||.|..||||||||||||||||:.|.:..||:|
Zfish   376 LVQKLNRSLAFKDEIYYSSKCSSVIGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSE 440

  Fly   493 QELYKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEES-KLPKPSYSHFTAEVHKSWANHYR 556
            ||.|:.||:....:.:.:|:.|.:|:|.|..||..:||||. :....|...|..::..:...|..
Zfish   441 QEEYEAEGVVWERVEYFNNKIICDLVEEKHKGIIAILDEECLRRGDASDITFLEKLEDTLGGHAH 505

  Fly   557 LGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF 621
            ....:.:..|..:.:..|| |.:.|:||.|.||...|::||||.|:..|:.::.:..|.::...|
Zfish   506 FITHKMANGKIRKAIGREE-FRLVHYAGEVNYNVNGFLDKNNDLLYRHLKEVLCQSTNHIVSQCF 569

  Fly   622 PSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQLKC 686
            .:......|..   .:..::||..|.:||:.|.....:::||||||......:|:..|...|:|.
Zfish   570 HADELMDQRRP---ETAATQFKLSLAKLMDILMSKEPSYVRCIKPNDGKQPGRFDEVLVRHQVKY 631

  Fly   687 SGTISVLELMEHGYPSRVLFADLYSMYKSVLP----------PELVSLPARTFCEAMFQSLNLSA 741
            .|.:..|.:...|:..|..:......|||:.|          ||.|:        .:.:.||...
Zfish   632 LGLMENLRVRRAGFAYRRSYEAFLERYKSLCPDTWPNWHGNLPEGVA--------TLVKHLNYKP 688

  Fly   742 KDFKFGITKVFFRPGK--FVEFDRIMRSDPENMLAIVAKVKKW-----------------LIRSR 787
            ::||.|.:|:|.|..:  |:..|.:   :.:.....|...|.|                 :|:|.
Zfish   689 EEFKLGRSKIFIRFPRTLFITEDAL---EAQKQTIAVTLQKSWRGYRERANYHRIRHAVIVIQSW 750

  Fly   788 WVKSALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPR---------YQGIGKINKIRT 843
            |..        :|.|.:..:|.:.....:...:||:.|.:  ||         :.....:.|::.
Zfish   751 WRG--------VKGRRKAKHRRQAADTIRNFIKGFILRNE--PRCPDNEYFLDHVRFSFLMKVKR 805

  Fly   844 NTLKTIEIASGLK-----------MGREEIISGVNDIYRQIDDAIKK 879
            |..|::...|..|           :.|..|.:.|||..|:|....:|
Zfish   806 NLPKSVLDKSWPKPPPSLTEASEHIHRICIRNLVNDYCRRIQPEWRK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	254/722 (35%)
		MYSc_Myo6	71..754	CDD:276833	250/707 (35%)
		RILP-like	<968..1015	CDD:304877
		Myosin-VI_CBD	1160..1246	CDD:293129
myo1ca	XP_005165404.1	MYSc	25..714	CDD:214580	260/742 (35%)
		MYSc_Myo1	44..701	CDD:276829	249/706 (35%)
		IQ	739..761	CDD:197470	5/29 (17%)
		Myosin_TH1	857..1026	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010