Protein Alignment jar and myo5b

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_021324561.1
• Gene: myo5b / 567402
• ZFINID: ZDB-GENE-031219-7
• Length: 1840
• Species: Danio rerio
• Alignment Length: 1291
• Identity: 380/1291 - (29%)
• Similarity: 599/1291 - (46%)
• Gaps: 250/1291 - (19%)

  Fly     2 LEDTQLVW-----VRDAAEG--YIQGRITEIGAKEFEVTPTDRKYPKRTCHFDDIHSSCDGPQDH 59
            :.|...||     ::|..||  .:..::.:....|:.:...|...|        ...:.|.....
Zfish    15 IPDPDEVWRSAEIIKDYKEGDTVLHLKLEDESTLEYPIGSKDNPLP--------FLRNPDILVGE 71

  Fly    60 DDNCELMLLNEATFLDNLKTRYYK-DKIYTYVANILIAVNPYREIKELYAPDTIKKYNGRSLGEL 123
            :|...|..|:|...|.|||.|:.: :.||||...:|:|:|||.:: .:|..:.|..|:|:::|::
Zfish    72 NDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQL-HIYGEEVINAYSGQNMGDM 135

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGP--IETKILDAN 186
            .||:||:|::|.:.|...:.:||||||||||||||.|.||.:::......||..  :|.|:|.::
Zfish   136 DPHIFAVAEEAFKQMARDEKNQSIIVSGESGAGKTVSAKYAMRFFATVGGSANDTNVEEKVLASS 200

  Fly   187 PVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVFYML 251
            |::||.||||||||:|||||||:|::.:|.:..::|..:..|||||||:..|:.||||||:||.|
Zfish   201 PIMEAIGNAKTTRNDNSSRFGKYIQIGFDRRYHIIGANMRTYLLEKSRVVFQAEEERNYHIFYQL 265

  Fly   252 LAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDYQHF 316
            .|.........|:|...:|:.|.|.....|        |.|                 ::|.:..
Zfish   266 CASCSLPEFKDLTLTSAEDFTYTSLGENIF--------IEG-----------------VNDAEDL 305

  Fly   317 HNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRG-GCQVSEASEQSLTITSGLLG 380
            ....:||..||:.:..::.|:.::|::|||||:   ||..:..| .|.::. ::..|.....|||
Zfish   306 VKTREALTMLGVKENHQMSIFKIIASILHLGNV---EIVQERDGESCHINR-NDTHLHHFCRLLG 366

  Fly   381 VDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPF 445
            ::|.::...|..|.:.:....:   |..:|..  :|.||||||||.||:.|||.||..||:|:..
Zfish   367 IEQEQMENWLCRRKLVTTSETY---VKNMPHS--QAVNARDALAKHIYAHLFDWIVEHINKSLHT 426

  Fly   446 QA-SNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFT 509
            .. .:.:||||||.|||.|.:||||||||||.|||||:.||.::.|.|||.|.:|.:....|.|.
Zfish   427 STKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEEYMKEQIPWTLIDFY 491

  Fly   510 DNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLPRSSRLKAHRTLRDE 574
            |||..|:|||||. ||..|||||.|:||.:..::..:::...:.......||.|          .
Zfish   492 DNQPCIDLIEAKL-GILDLLDEECKVPKGTDQNWAQKLYSKHSGSGHFEKPRMS----------N 545

  Fly   575 EGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLFPS--------GSSTS--- 628
            :.|:|.|||..|.|..:.|:|||.|.::.....:::.....|:..||..        ||.||
Zfish   546 KSFIVVHFADKVEYQCDGFLEKNRDTVYEEQINILKASKFQLVADLFDDAKDAAPHPGSKTSRIN 610

  Fly   629 VR---------GKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQL 684
            ||         .:.:..:||::|:..|..|||.|.....:::||||||.......|:...|:.||
Zfish   611 VRPAKPAPKGHNREHRKTVGTQFRNSLHLLMETLNATTPHYVRCIKPNDYKESFVFDSRRAVQQL 675

  Fly   685 KCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSL-PARTFCEAMFQSLNLSAKDFKFGI 748
            :..|.:..:.:...|||||..:.|.:|.|:.::..:.:|: ..:..|:.:.:.|......|:||.
Zfish   676 RACGVLETIRISAAGYPSRWTYPDFFSRYRVLMTKKDLSVGDKKQVCKNLLEILIKDPDKFQFGK 740

  Fly   749 TKVFFRPGKFVEFDRIMRSDPENMLAIVAKVKK----WLIRSRW---VKSAL------------- 793
            ||:|||.|:....:: :|:|......|  |::|    ||.|.|:   .|||:
Zfish   741 TKIFFRAGQVAYLEK-LRADKFRFACI--KIQKTVRGWLQRIRYRKIRKSAITLQRYGRGYLARR 802

  Fly   794 ----------GALC-----VIKLRNRIIYRNKCV-------------------------LIAQRI 818
                      ..:|     ::::|...:...:.|                         :|.|:.
Zfish   803 YAEMLRLTRAAVICQKQYRMVQVRREYLRVRRAVITIQAFTRGMFIRRLYQEFLLHHKAMIIQKT 867

  Fly   819 ARGFLARKQH-RPRYQGI---GKINKIRT-NTLKTIEIAS-------GLKMGREEIISGVNDIYR 871
            .||:|.||:: |.||..|   ....::|. ..||.::|.:       .|.:|.|   :.:..:.:
Zfish   868 VRGWLVRKKYQRSRYAAIVIQCFYRRVRAKRQLKQLKIEARSAEHFKKLNVGME---NKIVQLQK 929

  Fly   872 QIDDAIKKIKMNPRITQRE-MDSMYTVVMANMNKLTVDLNTKLKEQ----QQAEEQERLRKIQEA 931
            ::|:..|::|     :|.| :....||:...::||:.:|.|....|    |....||.|.|::..
Zfish   930 KMDNQSKELK-----SQNENLAVAKTVLETEVSKLSKELETLRTRQVAGTQMTSLQEELEKLRAE 989

  Fly   932 LEAERAAKEAEEQRQREEIENKR--LKAEMETRRKAAEAQRLRQEEEDRRAALALQEQ----LEK 990
            |:...|.|:..|    ||..|::  |:..:|...|.....:..:||.:||...:.|:|    .:|
Zfish   990 LQEAHAHKKLLE----EEFSNEKQGLEQRVEELEKENTVLKKEKEEMNRRIQTSTQDQGGDVSQK 1050

  Fly   991 EAK-----DDAKYRQQ--------LEQ-----------------ERRDHELALRLANESN----- 1020
            |::     ||.:.|.|        |||                 .||:......|.::||
Zfish  1051 ESRLQHELDDERQRYQNLVKEYSRLEQRYENLQEDMSSMKFHPGHRRNPSNQSSLGSDSNYPSIS 1115

  Fly  1021 ----GQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQKYDLS 1081
                |..:|:       :.....||..|......|...:..|.....:..:..|..|.|.: :||
Zfish  1116 LSEVGDTDDT-------IQQVEEMGIEKAAMDLSVFMKLQKRVRELEQERKRLQTNLDKVE-ELS 1172

  Fly  1082 KWKYSELR-----DAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENE 1132
            |.|.||.:     |.||  .|:......|||.....|     |.||      |.||
Zfish  1173 KRKGSEAKNSTSEDDIN--ADLAYNSLKRQELETENK-----KLKN------DLNE 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	8/48 (17%)
		MYSc_Myo6	71..754	CDD:276833	253/708 (36%)
		CBD_MYO6-like	765..913	CDD:409646	44/220 (20%)
		ERM_helical	<954..1020	CDD:466641	21/101 (21%)
		MYO6_MIU_linker	1002..1093	CDD:480843	25/121 (21%)
		MyUb_Myo6	1076..1116	CDD:439319	14/44 (32%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo5b	XP_021324561.1	COG5022	7..1371	CDD:227355	380/1291 (29%)
		MYSc_Myo5	83..746	CDD:276831	253/708 (36%)
		Myo5b_CBD	1461..1835	CDD:271261