Protein Alignment jar and myo7bb

DIOPT Version :10

• Sequence 1: NP_001014650.2
• Gene: jar / 42889
• FlyBaseID: FBgn0011225
• Length: 1268
• Species: Drosophila melanogaster
• Sequence 2: XP_021322881.3
• Gene: myo7bb / 566034
• ZFINID: ZDB-GENE-070912-482
• Length: 2160
• Species: Danio rerio
• Alignment Length: 1199
• Identity: 362/1199 - (30%)
• Similarity: 553/1199 - (46%)
• Gaps: 221/1199 - (18%)

  Fly     1 MLEDTQLVWVRDA----AEGYIQGRITEIG--------AKEFEVTPTDRKYPKRTCHFDDIH-SS 52
            ||:....||:..:    ..||:  :|:..|        .||..:...||...|      .:| :|
Zfish     3 MLKKGDHVWIESSIGVPIGGYV--KISGSGQYCLIDDEGKEHSIPEGDRAALK------PMHPTS 59

  Fly    53 CDGPQDHDDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPDTIKKYNG 117
            .:|.   ||...|..|:||..|.||..|:.:..||||:.::|:|:||| |:..:|..|.:::|:|
Zfish    60 VEGV---DDMICLGDLSEAGLLRNLFLRHKQGIIYTYIGSVLVAMNPY-EMLPIYTADQVQQYHG 120

  Fly   118 RSLGELPPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAGPIETKI 182
            |.|||||||:|||||....:||..|.:|..|:|||||||||||||.:|::|.........||.:|
Zfish   121 RKLGELPPHIFAIADSCYFNMRRNKRNQCCIISGESGAGKTESTKLILQFLAAVSGQHSWIEQQI 185

  Fly   183 LDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHV 247
            :.|||:|||||||||.||:|||||||::|:.::....:.|.::..|||||||:|.|:.:|||||:
Zfish   186 IQANPILEAFGNAKTIRNDNSSRFGKYVEIFFNKAGVIEGAHMEQYLLEKSRVCHQALQERNYHI 250

  Fly   248 FYMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDD 312
            ||.:|||.....:..||||...::.||:.......:.:                         ||
Zfish   251 FYCMLAGMQSDHKKTLSLGDASEFNYLTEGDCLTCDGR-------------------------DD 290

  Fly   313 YQHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSG 377
            ...|..:..||..|..:|.:...|:.|:||:||:|||.|:....:....|.|..:|.  .::.:.
Zfish   291 ADEFARIRSALKVLTFTDRDCWEIFKLLAAILHMGNIDFQSTIMNNMDSCDVLSSSH--FSVIAK 353

  Fly   378 LLGVDQTEL------RTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIV 436
            ||.||...|      |:.:.:|.|.:|           ||...:|::.|||.|||:|.|||..:.
Zfish   354 LLEVDDAALDKSLTHRSFMTNREMVTK-----------PLSSEQATDIRDAFAKALYGRLFVWMF 407

  Fly   437 GLINQSI--PFQASNFY----IGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQEL 495
            ..||.:|  |......|    ||:|||.|||.|..|||||.|||:.||.||:||..::.|.||:.
Zfish   408 TKINSAIHKPQTDEPSYTRQSIGLLDIFGFENFPQNSFEQLCINFANEHLQQFFVRHVFKLEQDE 472

  Fly   496 YKREGLNVPEITFTDNQDIIELIEAKSNGIFTLLDEESKLPKPSYSHFTAEVHKSWANHYRLGLP 560
            |.:||::...|.|.|||..::|:..|...|..|:||||..||.:.:   ..::|....|....|.
Zfish   473 YTKEGISWKRIAFNDNQKTLDLLALKPLNILALIDEESHFPKGTDA---TMLNKLSQEHKGNKLY 534

  Fly   561 RSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQTLF---- 621
            .||| ..||.     .|.|:||||.|.|:.|.|:|||.|.:...:..|:::..|.||:.:|
Zfish   535 ISSR-GDHRI-----HFGVQHFAGLVYYDCEGFLEKNRDTVSMDILELIRKSSNKLLKQIFEKEI 593

  Fly   622 -----------------PSGSSTSVRGKLNFIS-VGSKFKTQLGELMEKLEQNGTNFIRCIKPNS 668
                             |..|...|......|| :..:|:..|..||:.|......||||.|||.
Zfish   594 NVNSVKNSNKMNKAVMTPKNSLRQVNESRRQISTLSGQFRQSLDSLMKALSLCQPFFIRCFKPND 658

  Fly   669 KMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKSVL-----PPELVSLPART 728
            |.:...|...|.:.||:.||.:..:.:.:.|||.|..|.|....|:::|     .|.  :.||..
Zfish   659 KKLPMVFNRELCMQQLRYSGMLETIRIRKLGYPIRHTFKDFLHRYRALLKSIDCDPN--TEPAAK 721

  Fly   729 FCEAMFQSLNLSAKDFKFGITKVFFR--PGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKS 791
            .|.|:.::|....:|:|.|.||||.|  ...::|.:|...           ..:|.||..|
Zfish   722 CCAAICRTLIKDEEDWKIGKTKVFLRGHHDTYLELERAQE-----------LYRKALIIQR---- 771

  Fly   792 ALGALCVIKLRNRIIYRNKCVLIAQRIARGFLARKQHRPRYQGIGKIN-KIRTNTL--------- 846
               .:...|.|...|.:.|..|:.|:..||:..::......||..::. |:|:..|
Zfish   772 ---VMLAHKDRKNFINKRKAALVLQKNWRGYKEKRDFCTVKQGFARLQAKVRSRKLHEEYMRRRA 833

  Fly   847 ---------KTIEIASGLKMGREEII------SGVNDIYRQIDDAIKKIKMNPRITQREMDSMYT 896
                     :.:.....||..:|.:|      .|:  :.|:   ::|::|....:|.:|..:...
Zfish   834 AAIVLQTQTRGLLARKELKSKKEAVILLQAQTRGL--LARK---SLKRMKSEEFLTAQEKQAQEL 893

  Fly   897 VVMANMNKLTVDL--NTKLKEQQQAEEQERLRKIQEALEAERAAKEAEEQRQREEIENKRLKAE- 958
            ..:....:|...|  |.:..:.|..|::|.:..|...|....|.:|.......||.|.:..|.|
Zfish   894 AALELQQRLEELLRKNEETAKSQNNEDEEMVENIFNFLPTAIAGQEGPAPEGFEEFEAEPAKLEE 958

  Fly   959 --------METR----RKAAEAQRLRQEEEDRR---------AALALQEQLEKEAKDDAKYRQQL 1002
                    :||:    .:::|..::::|||:..         |:|..|     .|...:..:|:|
Zfish   959 VELIESPVVETKVMSIPESSEDHQVKEEEEEEEDDEFSFSKFASLHFQ-----GASTHSYIQQRL 1018

  Fly  1003 EQERRDHE-------------LALRLANESNGQVED-----SPPVIRNGVNDASPMGPNKLISFS 1049
            .|....||             :.||...:.....::     :.|:.||       :|..:....|
Zfish  1019 RQPLLYHEDEGDTLACLTVWWIILRFMGDLPEPKQERVSAMADPIQRN-------LGQRQARRLS 1076

  Fly  1050 QVVSNIASRYLNKSENVRAQQQALGKQKY 1078
            .:| .:..::|.|.   ..||:..||:|:
Zfish  1077 NLV-GLDQKFLRKK---MKQQKGGGKRKH 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..49	CDD:460670	11/53 (21%)
		MYSc_Myo6	71..754	CDD:276833	266/721 (37%)
		CBD_MYO6-like	765..913	CDD:409646	30/174 (17%)
		ERM_helical	<954..1020	CDD:466641	19/100 (19%)
		MYO6_MIU_linker	1002..1093	CDD:480843	19/95 (20%)
		MyUb_Myo6	1076..1116	CDD:439319	1/3 (33%)
		Myosin-VI_CBD	1160..1246	CDD:465157
myo7bb	XP_021322881.3	None