DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment jar and myo1f

DIOPT Version :9

Sequence 1:	NP_001014650.2	Gene:	jar / 42889	FlyBaseID:	FBgn0011225	Length:	1268	Species:	Drosophila melanogaster
Sequence 2:	NP_001243600.1	Gene:	myo1f / 565345	ZFINID:	ZDB-GENE-081104-506	Length:	1095	Species:	Danio rerio

Alignment Length:	1192	Identity:	325/1192 - (27%)
Similarity:	520/1192 - (43%)	Gaps:	247/1192 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DDNCELMLLNEATFLDNLKTRYYKDKIYTYVANILIAVNPYREIKELYAPD-TIKKYNGRSLGEL 123
            ||...|..:.|...::|||.|:..|.|:||:..:||:|||::::.  |..| .|:.|.|.:..|.
Zfish    18 DDMVLLSKITEDAIVENLKKRFLDDYIFTYIGPVLISVNPFKQMP--YFTDREIELYQGAAQYEN 80

  Fly   124 PPHVFAIADKAIRDMRVYKLSQSIIVSGESGAGKTESTKYLLKYLCYSHDSAG-----PIETKIL 183
            |||::|:.|...|:|.:...:|.:|:|||||||||.:.||::.|:  |..|.|     .::..||
Zfish    81 PPHIYALTDNMYRNMMIDSENQCVIISGESGAGKTVAAKYIMGYI--SKVSGGGSKVQHVKDIIL 143

  Fly   184 DANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKCQVVGGYISHYLLEKSRICTQSAEERNYHVF 248
            .:||:|||||||||.||||||||||:.|:.:....:..||.||::||||||:.:|:..|||:|:|
Zfish   144 QSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENERNFHIF 208

  Fly   249 YMLLAGAPQQLRDKLSLGKPDDYRYLSGCTQYFANAKTEQLIPGSQKSKNHQQKGPLKDPIIDDY 313
            |.|:.|...|.::.|.:..||.|.||:                         |.|..|....:|.
Zfish   209 YQLIDGCTPQQKEGLGIMTPDYYYYLN-------------------------QSGTYKVDGTNDS 248

  Fly   314 QHFHNLDKALGRLGLSDTEKLGIYSLVAAVLHLGNIAFEEIPDDVRGGCQVSEASEQSLTITSGL 378
            :.|....:|:..:|:.:..:.....:||.:||||:|.|.|:      |......|...|...:.|
Zfish   249 KDFQETMEAMQVIGIPEMHQTLALQIVAGILHLGSINFIEV------GNYGQVESTDLLAFPAYL 307

  Fly   379 LGVDQTELRTALVSRVMQSKGGGFKGTVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSI 443
            ||:||..|:..|.||:|.||..| |...|.|.|.:.:|.:.|||||||:|:||||.:|..||:::
Zfish   308 LGIDQNRLQEKLTSRIMDSKWAG-KTESINVTLNLEQARHTRDALAKALYTRLFDYLVEEINKAM 371

  Fly   444 PFQASNFYIGVLDIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITF 508
            ........:|||||.|||.|..|.|||||||:.|||||:.|.:..||.|||.|.:||:....|.:
Zfish   372 QKPIEELSVGVLDIYGFEIFQRNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIKWTPIEY 436

  Fly   509 TDNQDIIELIEAKSN--GIFTLLDEE----------------SKLPKP--SYSHFTAEVHKSWAN 553
            .:|:.:.:|||.|.:  ||.::||:.                .||...  ::.||     .||
Zfish   437 FNNKIVCDLIENKLSPPGIMSVLDDVCATMHATKDGADMTLLQKLQNAVGTHDHF-----NSW-- 494

  Fly   554 HYRLGLPRSSRLKAHRTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQECDNPLLQ 618
                                ..||::.|:||.|.|:...|.|:|.|.|...|..|:|......:|
Zfish   495 --------------------NSGFIIHHYAGKVSYDINGFCERNRDVLFPDLIELMQSSQYDFIQ 539

  Fly   619 TLFPSGSSTSVRGKLNFISVGSKFKTQLGELMEKLEQNGTNFIRCIKPNSKMIDRQFEGSLALAQ 683
            :|||...:|..:|:..  :.|||.|.|..||:..|.:...::|||||||.....:.:|.|.|..|
Zfish   540 SLFPENLNTDKKGRPT--TAGSKIKRQANELVSTLMKCTPHYIRCIKPNETKRPKDWEESRARHQ 602

  Fly   684 LKCSGTISVLELMEHGYPSRVLFADLYSMYKSVLPPELVSLPARTFCEA-----MFQSLNLSAKD 743
            ::..|....:.:...|:..|.:|......| ::|..|  :.|.....|.     :.:::|:....
Zfish   603 VEYLGLRENIRVRRAGFAYRRIFPKFLHRY-AILTAE--TWPCWRGAEQQGVLHLLRTVNMETDQ 664

  Fly   744 FKFGITKVF------------FRPGKFVEFDRIMRSDPENMLAIVAKVKKWLIRSRWVKSALGAL 796
            ::.|.:|:|            .|..||..|.|          .|....:|::.|.::.:....|.
Zfish   665 YQMGRSKIFIKNPESLFLLEEMRERKFDTFAR----------TIQKAWRKYIARRKYEQMREEAS 719

  Fly   797 CVI----KLRNRIIYRNKCVLIAQRIA-------RGFLARKQHRPRYQGIGKINKIRTNTLKTIE 850
            .::    :.|...|.||   .:...:.       |.|:|:::.......:.|.:: |..::|...
Zfish   720 DILYNSKERRRNSINRN---FVGDYLGMEDRPELRQFMAKRERVDFADSVNKFDR-RFKSIKRDL 780

  Fly   851 IASGLK---MGREEIISG-----VNDIY-RQID-DAIKKIKMNPR------ITQREMDSMYTVVM 899
            |.|...   :|||:|..|     :.::. |::| ..|:.:.::.|      :.:.|.||:...:.
Zfish   781 ILSPKSIYLIGREKIKKGPEKGQIKEVLKRRLDISGIRSVSLSTRQDDFFILHETEYDSLLESMF 845

  Fly   900 --------------ANMNKLTVDLNTKL----KEQQQAEEQERLRKIQEALEAERAAKEAEEQRQ 946
                          ...:|||:..:.:|    |::.......|:...|.. :|:.|..:|..:..
Zfish   846 KTEFLTLLCKRYEEQTRSKLTLSFSDRLQFNVKKEGWGGGSTRMVVFQRG-QADEAVIKAGGKTL 909

  Fly   947 REEIENKRLKAEMETRRKAAEAQRLRQEEEDRRAALALQEQLEKEAKDDAKYRQQLEQERRDHEL 1011
            ...:.:...|....||:...::...|.:.:.|..          .....|::.:...|:::..|:
Zfish   910 TVSVGDGLPKTSKPTRKGMPQSHGGRSQPQHRGG----------HQNGAAQFHRGGGQQQQQKEV 964

  Fly  1012 ALRLANESNGQVEDSPPVIRNGVNDASPMGPNKLISFSQVVSNIASRYLNKSENVRAQQQALGKQ 1076
            ...:      .|..:||          |..|.|                            ||.|
Zfish   965 TYSM------PVRHNPP----------PSNPLK----------------------------LGSQ 985

  Fly  1077 KYDLSKWKYSELRDAINTSCDIELLEACRQEFHRRLKVYHAWKAKNRKRTTMDENERAPRSVMEA 1141
            |.....      |...|.|.:::.|....|          ......||::.......||.|
Zfish   986 KNQRGS------RPVQNQSTNLDFLNVPDQ----------GMSGMQRKKSISQRPPPAPSS---- 1030

  Fly  1142 AFKQPPLVQPIQEIVTAQHRYF 1163
              :..|..:|......|.::||
Zfish  1031 --RPKPQARPQGPRCRALYQYF 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
jar	NP_001014650.2	Myosin_N	7..45	CDD:280832
		Myosin_head	59..754	CDD:278492	249/736 (34%)
		MYSc_Myo6	71..754	CDD:276833	245/725 (34%)
		RILP-like	<968..1015	CDD:304877	5/46 (11%)
		Myosin-VI_CBD	1160..1246	CDD:293129	2/4 (50%)
myo1f	NP_001243600.1	MYSc	10..688	CDD:214580	249/737 (34%)
		MYSc_Myo1	29..675	CDD:276829	245/713 (34%)
		Myosin_TH1	715..897	CDD:283635	32/186 (17%)
		SH3_MyoIe_If_like	1042..1094	CDD:212761	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010